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Association Between the Polymorphism of Aldehyde Dehydrogenase 2 Gene and Cerebral Infarction in a Hakka Population in Southern China
Genetic factors play an important role in determining the susceptibility to ischemic stroke. Herein, we examined the association of an aldehyde dehydrogenase 2 ( ALDH2 ) gene polymorphism with cerebral infarction. Patients with cerebral infarction ( n = 963) and healthy controls ( n = 921) were in...
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Published in: | Biochemical genetics 2020-04, Vol.58 (2), p.322-334 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Genetic factors play an important role in determining the susceptibility to ischemic stroke. Herein, we examined the association of an aldehyde dehydrogenase 2 (
ALDH2
) gene polymorphism with cerebral infarction. Patients with cerebral infarction (
n
= 963) and healthy controls (
n
= 921) were included. Genotyping was performed using gene chip platform analysis, and Sanger sequencing was used to confirm
ALDH2
genotypes. The risk prediction of
ALDH2
polymorphisms for cerebral infarction was examined under three genetic modes of inheritance. For males,
ALDH2*2/*2
genotype was a significant risk factor for cerebral infarction in the co-dominant model (age-, smoking-, and drinking-adjusted OR 1.514, 95% CI 1.005–2.282,
p
= 0.047) and the recessive model (age-, smoking-, and drinking-adjusted OR 1.601, 95% CI 1.078–2.379,
p
= 0.020). However, for females,
ALDH2*2/*2
genotype was a protective factor for cerebral infarction in the co-dominant model (age-, smoking-, and drinking-adjusted OR 0.450 95% CI 0.215–0.941,
p
= 0.034) and the recessive model (age-, smoking-, and drinking-adjusted OR 0.440, 95% CI 0.214–0.903,
p
= 0.025). Further, logistic regression analysis revealed that age, smoking, hypertension, hyperlipidemia, and hypercholesterolemia were significant risks for the presence of cerebral infarction. In conclusion, these findings support an association of
ALDH2
gene polymorphisms with ischemic stroke in a Chinese Hakka population. In particular, homozygote
ALDH2*2/*2
may be a risk factor for cerebral infarction in males, but contribute to reduced risk for cerebral infarction in females. |
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ISSN: | 0006-2928 1573-4927 |
DOI: | 10.1007/s10528-020-09950-5 |