Impact of atrial fibrillation burden on cognitive function after left atrial ablation – Results of the MACPAF study

•Atrial fibrillation burden was low after ablation therapy.•Atrial fibrillation burden had divergent effects on executive functions and learning.•Atrial fibrillation burden had no impact on overall cognitive performance. Atrial fibrillation (AF) is associated with cognitive decline and dementia irre...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2020-03, Vol.73, p.168-172
Main Authors: Herm, Juliane, Schirdewan, Alexander, Koch, Lydia, Wutzler, Alexander, Fiebach, Jochen B., Endres, Matthias, Kopp, Ute A., Haeusler, Karl Georg
Format: Article
Language:English
Subjects:
Ablation
Atrial fibrillation burden
Cognitive function
Dementia
Insertable loop recorder
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Summary:•Atrial fibrillation burden was low after ablation therapy.•Atrial fibrillation burden had divergent effects on executive functions and learning.•Atrial fibrillation burden had no impact on overall cognitive performance. Atrial fibrillation (AF) is associated with cognitive decline and dementia irrespective of AF-related ischemic stroke. We investigated whether AF burden after ablation in patients with symptomatic paroxysmal AF has an impact on cognitive function. After enrolment to the prospective MACPAF study, study patients received an insertable loop recorder (ILR) and underwent serial neurological/cognitive assessment. To compare cognitive function, the delta of baseline and six months test results (Δpre/post) and a score to assess overall cognitive performance were computed. Thirty patients (median age 65 years (IQR 57–69), 40% female) were divided into groups according to median AF burden (
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2019.12.030