Modulation of the Somatosensory Blink Reflex in the Peripersonal Space Is Defective in Episodic Migraine

Abstract Objective In migraine, there is an altered behavior of patients during the attack and an altered connectivity in the cortical structures modulating and encoding the sensation and pain. Thus, we hypothesized that the extent of the peripersonal space (PPS) and the responses in the PPS may cha...

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Bibliographic Details
Published in:Pain medicine (Malden, Mass.) Mass.), 2020-08, Vol.21 (8), p.1663-1667
Main Authors: Ayas, Selahattin, Kızıltan, Meral E, Karaali-Savrun, Feray, Gündüz, Ayşegül
Format: Article
Language:English
Subjects:
Blink reflex
Blinking
Cross-Sectional Studies
Development and progression
Forearm
Hand
Headache
Health aspects
Humans
Latency
Migraine
Migraine Disorders
Pain perception
Personal Space
Somatosensory system
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Summary:Abstract Objective In migraine, there is an altered behavior of patients during the attack and an altered connectivity in the cortical structures modulating and encoding the sensation and pain. Thus, we hypothesized that the extent of the peripersonal space (PPS) and the responses in the PPS may change during a migraine attack. For this reason, we analyzed the modulation of somatosensory blink reflex (SBR) in the PPS during episodic migraine. Design Cross-sectional assessment of modulation of SBR in patients with migraine. Setting Headache outpatient clinic of a tertiary referral center. Subjects We included 22 patients with episodic migraine, of whom 13 individuals were in the interictal period and nine were experiencing a headache episode. We also included 14 healthy individuals. The three groups were similar in age and gender. Methods SBR was recorded when the participants were sitting with their forearm in the extrapersonal space and also when their hands were in the PPS surrounding the face. Latency, amplitude, and area under the curve (AUC) were measured and compared. Results The amplitude and AUC of the SBR were significantly higher in patients during the attack compared with healthy subjects. The magnitude of the SBR was increased in the PPS in healthy subjects, whereas the increase was not significant in patients during the attack or in the interictal period. Conclusions We think that the modulation in the PPS is defective in patients with migraine both during the acute attack and in the interictal phase, suggesting diminished top-down modulation of the SBR.
ISSN:1526-2375
1526-4637
DOI:10.1093/pm/pnz328