Evolution of Graph Theory in Dynamic Functional Connectivity for Lateralization of Temporal Lobe Epilepsy

Resting-state functional magnetic resonance imaging (rsfMRI) has described the functional architecture of the human brain in the absence of any task or stimulus. Since the functional connectivity (FC), has non-stationary nature, it is evidenced to be varying over time. Using dynamic functional conne...

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Bibliographic Details
Main Authors: Fallahi, Alireza, Nazem-Zadeh, Mohammad-Reza, Baniasad, Fatemeh, Lotfi, Nastaran, Mirbagheri, Mehdi, Mohammadi-Mobarakeh, Neda, Tapak, Leili, Hashemi-Fesharaki, Seyed Sohrab, Pooyan, Mohammad, Mehvari-Habibabadi, Jafar
Format: Conference Proceeding
Language:English
Subjects:
Biomedical imaging
Epilepsy
Functional magnetic resonance imaging
Graph theory
Microsoft Windows
Temporal lobe
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Summary:Resting-state functional magnetic resonance imaging (rsfMRI) has described the functional architecture of the human brain in the absence of any task or stimulus. Since the functional connectivity (FC), has non-stationary nature, it is evidenced to be varying over time. Using dynamic functional connectivity, six graph theoretical characteristics were measured and compared between left and right temporal lobe epilepsy (TLE). We also obtain a trend for each characteristic in the time course of experiments. The results demonstrated that the static connectivity analysis failed to fully separate the left and right TLE patients for some characteristics, whereby the dynamic analysis has been shown capable of identifying the laterality. Furthermore, the results suggest that the temporal trend of some graph theoretical characteristics can be exploited as a novel marker for TLE laterality.
ISSN:1558-4615
2694-0604
DOI:10.1109/EMBC.2019.8856717