Comparison of Low-Density Lipoprotein Cholesterol Concentrations by Direct Measurement and by Friedewald Calculation

The purpose of this study was to compare Friedewald-calculated and directly measured low-density lipoprotein cholesterol (LDL-C) levels. LDL-C is routinely estimated by the Friedewald formula in clinical practice. However, unreliability of the Friedewald-calculated LDL-C appears at lower LDL-C level...

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Bibliographic Details
Published in:The American journal of cardiology 2020-03, Vol.125 (6), p.866-873
Main Authors: Sung, Ki-Chul, Kwon, Chang Hee, Lee, Mi Yeon, Kwon, Min-Jung, Lee, Ju Hee, Jung, Mi-Hyang, Shin, Jeong-Hun
Format: Article
Language:English
Subjects:
Cholesterol
Density
Hospitals
Levels
Lipoproteins
Low density lipoprotein
Mathematical analysis
Measurement methods
Medical laboratories
Medical screening
Methods
Population
Quality control
Reclassification
Sensitivity
Teaching methods
Triglycerides
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Summary:The purpose of this study was to compare Friedewald-calculated and directly measured low-density lipoprotein cholesterol (LDL-C) levels. LDL-C is routinely estimated by the Friedewald formula in clinical practice. However, unreliability of the Friedewald-calculated LDL-C appears at lower LDL-C level or high triglyceride levels. We examined 147,143 Korean adults who underwent a comprehensive health examination in 2017. After excluding subjects with calculated Friedewald LDL-C
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2019.12.036