Effect of the brain-derived neurotrophic factor gene Val66Met polymorphism on sensory-motor integration during a complex motor learning exercise

•The BDNF Met allele is related to lower performance in motor learning.•Presence of the BDNF Met allele leads to a different SMI pattern.•BDNF Met allele is associated with a short-lived high AF during motor learning.•Basket performance changes are negatively correlated with SMI changes at ISI 35-ms...

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Published in:Brain research 2020-04, Vol.1732, p.146652-146652, Article 146652
Main Authors: Deveci, Sule (Şule), Matur, Zeliha, Kesim, Yesim (Yeşim), Senturk (Şentürk), Gokce (Gökçe), Sargın-Kurt, Gulcan (Gülcan), Ugur (Uğur), Sibel Aylin, Oge (Öge), Ali Emre
Format: Article
Language:English
Subjects:
BDNF Met allele
Brain-derived neurotrophic factor
Motor skill learning
Sensory-motor integration
Transcranial magnetic stimulation
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Summary:•The BDNF Met allele is related to lower performance in motor learning.•Presence of the BDNF Met allele leads to a different SMI pattern.•BDNF Met allele is associated with a short-lived high AF during motor learning.•Basket performance changes are negatively correlated with SMI changes at ISI 35-ms. The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism may cause impairment in short-term motor learning by reducing activity-dependent BDNF expression, which causes alterations in synaptic plasticity by changing glutamatergic and GABAergic synaptic transmissions. Sensory-motor integration (SMI) plays an important role in motor learning. In this study, we investigated the role of this polymorphism on SMI during a complex motor learning practice. Forty-three healthy participants performed standardized 5-day basketball shooting exercises under supervision. Electrophysiologic SMI studies were performed before the first day exercise (T0) and after the first and fifth day exercises (T1 and T2, respectively). SMI was studied using electrical median nerve stimulation at the wrist, followed by transcranial magnetic stimulation (TMS) of the contralateral motor cortex with various inter-stimulus intervals (ISIs). Recordings were made from the thenar and forearm flexor muscles. Participants were divided into two groups according to their BDNF genotype. Group 1 consisted of 26 subjects with the Val66Val genotype and group 2 included 17 subjects with the BDNF Met allele. Group 2 had a lower increase in basketball scores at day 5. Moreover, they had higher afferent facilitation for the responses recorded from both thenar and forearm flexor muscles at T1, but these changes could not be maintained until T2. This non-persistent early hyper-responsivity of the sensory-motor cortex in subjects with the BDNF Met allele might be explained by a transient upsurge of cortical excitability to compensate the insufficient cortical plasticity during motor learning, which could be considered as a sign of lower performance in motor skill learning.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2020.146652