A Regenerative Medicine Approach to the Treatment of Hearing, Balance, and Olfactory Disorders: What Is in the Future for Otolaryngology?

ABSTRACT Regenerative medicine is being applied to many fields of medicine and is now starting to be considered and developed for application to treat hearing, balance, olfaction, and voice disorders. This special issue of the Anatomical Record with a series of over 20 papers covers many aspects of...

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Bibliographic Details
Published in:Anatomical record (Hoboken, N.J. : 2007) N.J. : 2007), 2020-03, Vol.303 (3), p.385-389
Main Author: Van De Water, Thomas R.
Format: Article
Language:English
Subjects:
3D cell culture
Adipose tissue
balance
CRISPR
gene editing
gene therapy
Genome editing
hearing
Hearing Disorders - therapy
Humans
Inner ear
Olfaction
Olfaction disorders
Olfaction Disorders - therapy
Otolaryngology - trends
Progenitor cells
Regenerative Medicine
Stem cell transplantation
Stem cells
Therapeutic applications
Umbilical cord
Vestibular Diseases - therapy
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Summary:ABSTRACT Regenerative medicine is being applied to many fields of medicine and is now starting to be considered and developed for application to treat hearing, balance, olfaction, and voice disorders. This special issue of the Anatomical Record with a series of over 20 papers covers many aspects of gene and stem cell therapies as they are developed for clinical applications in both in vitro and in vivo laboratory studies. These studies cover a wide range of approaches from gene editing in zebrafish with the latest technology (i.e., CRISPR/Cas9) to the isolation of human inner ear progenitor cells, to tracking transplanted human umbilical cord stem cells in mini pigs, to the in vitro building of graft tissues to repair tracheal defects with adipose tissue‐derived stem cells. Anat Rec, 303:385–389, 2020. © 2019 American Association for Anatomy
ISSN:1932-8486
1932-8494
DOI:10.1002/ar.24337