Vitamin D supplementation has no effects on progression of motor dysfunction in amyotrophic lateral sclerosis (ALS)

To investigate the effects of cholecalciferol supplementation on the progression of motor disability in a cohort of amyotrophic lateral sclerosis (ALS) patients with low blood 25-hydroxyvitamin D3 [25(OH)D] levels, on the basis of the hypothesis of potential neuroprotective effects of vitamin D supp...

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Published in:European journal of clinical nutrition 2020-01, Vol.74 (1), p.167-175
Main Authors: Trojsi, Francesca, Siciliano, Mattia, Passaniti, Carla, Bisecco, Alvino, Russo, Antonio, Lavorgna, Luigi, Esposito, Sabrina, Ricciardi, Dario, Monsurrò, Maria Rosaria, Tedeschi, Gioacchino, Santangelo, Gabriella
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - drug therapy
Blood
Calciferol
Cholecalciferol
Complications
Covariance
Dietary Supplements
Disabled Persons
Humans
Motor Disorders
Neuroprotection
Patients
Pretreatment
Serum levels
Statistical analysis
Statistical methods
Supplements
Vitamin D
Vitamin D Deficiency - complications
Vitamin D Deficiency - drug therapy
Vitamin deficiency
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Summary:To investigate the effects of cholecalciferol supplementation on the progression of motor disability in a cohort of amyotrophic lateral sclerosis (ALS) patients with low blood 25-hydroxyvitamin D3 [25(OH)D] levels, on the basis of the hypothesis of potential neuroprotective effects of vitamin D supplementation. Forty-eight ALS patients, 34 with deficient ( 0.05) and UMN (p > 0.05) among the patient groups who underwent 3 different doses of cholecalciferol. Conversely, the treatment with 75.000 IU/month or 100.000 IU/month induced a significant increase in serum levels of 25(OH)D in comparison with the supplementation with 50.000 IU/month; no significant differences were found between 75.000 IU/month and 100.000 IU/month. Our findings highlighted that 6-month supplementation of vitamin D in ALS patients had no significant effects on motor dysfunction. However, it is recommended to prevent medical complications of vitamin D deficiency in ALS patients as well as in other populations of neurodegenerative patients, characterized by low mobility and decreased sun exposure.
ISSN:0954-3007
1476-5640
DOI:10.1038/s41430-019-0448-3