Survival in breast cancer patients with spine metastases: Prognostic assessment involving molecular markers

To clarify and update the prognostic assessment for heterogeneous population of patients with breast cancer and spine metastases (SpM), using molecular markers. The patient data used in this study was obtained from a French national multi-center database of patients treated for breast cancer with Sp...

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Bibliographic Details
Published in:European journal of surgical oncology 2020-06, Vol.46 (6), p.1021-1027
Main Authors: Amelot, Aymeric, Terrier, Louis-Marie, Cristini, Joseph, Buffenoir, Kévin, Pascal-Moussellard, Hugues, Carpentier, Alexandre, Bonaccorsi, Raphael, Le Nail, Louis-Romée, Mathon, Bertrand
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Female
Follow-Up Studies
France - epidemiology
Genotype subtype
Humans
Middle Aged
Neoplasm Metastasis
Overall survival
Prognosis
Prospective Studies
Spinal Neoplasms - metabolism
Spinal Neoplasms - mortality
Spinal Neoplasms - secondary
Spine metastases
Survival Rate - trends
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Summary:To clarify and update the prognostic assessment for heterogeneous population of patients with breast cancer and spine metastases (SpM), using molecular markers. The patient data used in this study was obtained from a French national multi-center database of patients treated for breast cancer with SpM between 2014 and 2017. 556 SpM cases were diagnosed. Median overall survival (OS) time for all patients following the SpM event was 43.9 months. First, we confirmed 3 previously known significant prognostic factors for survival of patients with SpM: young age [HR: 2.019, 95% CI 1.343–3.037; p = 0.001], good WHO status [ Status 0 HR: 2.823, 95% CI 1.231–3.345; p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2019.12.026