Laser-ablation-synthesized nanoparticles and animal cell lines studies

Nanoparticles (NPs) synthesized by laser ablation in distilled water were used to study their biological effect on normal and cancer cells. Parameters such as cell morphology, cell proliferation and viability were examined for treated cell lines, and the effect was represented in terms of cells cyto...

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Bibliographic Details
Published in:	Journal of biosciences 2019-12, Vol.44 (6), p.1-8, Article 135
Main Authors:	Mahadevaiah, Kurrey, Nawneet K, Gowtham, G K, Somshekar, R
Format:	Article
Language:	eng
Subjects:	Ablation Animals Apoptosis Apoptosis - drug effects Biological effects Biomedical and Life Sciences Biomedicine Biotechnology Breast Breast cancer Cancer Cell Biology Cell death Cell Line, Tumor Cell morphology Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cells Colon Cytology Cytotoxicity Distilled water DNA DNA fragmentation DNA Fragmentation - drug effects Fibroblasts - drug effects Humans Laser ablation Laser Therapy Lasers Life Sciences Lines Melanoma Mice Microbiology Morphology Nanoparticles Nanoparticles - chemistry Nanoparticles - radiation effects Nanoparticles - therapeutic use Neoplasms - drug therapy NIH 3T3 Cells Plant Sciences Procedures Proliferation Synthesis Toxicity Viability Zoology
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Summary:	Nanoparticles (NPs) synthesized by laser ablation in distilled water were used to study their biological effect on normal and cancer cells. Parameters such as cell morphology, cell proliferation and viability were examined for treated cell lines, and the effect was represented in terms of cells cytotoxicity using standard procedures. The study reveals the higher cytotoxic effect of nanoparticles on cancerous cells of breast, melanoma and colon origin compared to normal fibroblast cells NIH-3T3. Furthermore, DNA fragmentation assay results demonstrated the apoptosis mediated cell death in nanoparticle-treated cancer cells. The distinct role of nanoparticles in normal and cancer cells of different origin showed that nanoparticles were specific to cause cytotoxicity in particular cancer cells type. NPs exhibit cytotoxic effects in cancer cells by inducing apoptosis. These studies provide fundamental evidence for the easy, simple and safe mode of nanoparticles synthesis and their application in cancer cells death.
ISSN:	0250-5991 0973-7138