Determination of pentraxin 3 levels in diagnosis of appendicitis in children

Background The aim of this study is to determine whether pentraxin 3 (PTX3) levels can be used in the diagnosis of appendicitis in children. Methods Fifteen children under 18 years old, who gave blood samples for reasons other than inflammatory conditions, and 40 children who were proved to have app...

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Bibliographic Details
Published in:Pediatrics international 2020-05, Vol.62 (5), p.624-628
Main Authors: Ates, Ufuk, Bahadir, Kutay, Ergun, Ergun, Gollu, Gulnur, Durmaz, Mustafa, Gunay, Fatih, Erguder, Imge, Bingol‐Kologlu, Meltem, Yagmurlu, Aydin, Dindar, Huseyin, Cakmak, Murat
Format: Article
Language:English
Subjects:
Abdominal Pain - diagnosis
Appendicitis
Appendicitis - blood
Appendicitis - diagnosis
Biomarkers - blood
C-Reactive Protein - analysis
Child
Children
C‐reactive protein
Diagnosis
Female
Humans
Inflammation
Inflammation - diagnosis
Leukocytes - metabolism
Lymphocyte Count
Male
Neutrophils - metabolism
Pain
Pediatrics
Pentraxin 3
Pentraxins
ROC Curve
Serum Amyloid P-Component - analysis
Surgery
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Summary:Background The aim of this study is to determine whether pentraxin 3 (PTX3) levels can be used in the diagnosis of appendicitis in children. Methods Fifteen children under 18 years old, who gave blood samples for reasons other than inflammatory conditions, and 40 children who were proved to have appendicitis (non‐perforated or perforated) between August 2017 and January 2018, were enrolled in the study. Patients were classified into subgroups: group 1 (healthy children without any sign of inflammation, n = 15), group 2 (non‐perforated appendicitis, n = 25), and group 3 (perforated appendicitis, n = 15). Results The median PTX3 value was 1.01 ng/mL (minimum value: 0.82, maximum: 1.28) in the control group. The median PTX3 values prior to surgery were 20.68 ng/mL (minimum: 1.02, maximum: 28.471) and 1.46 (minimum: 1.05, maximum: 23.421) ng/mL for non‐perforated appendicitis and perforated appendicitis respectively. The PTX3 levels were significantly higher in groups 2 and 3 than in group 1 (P 
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.14131