Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly

Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of β-annulus-S-peptide and the interaction between S-peptide moiety and S-protein. The β-annulus-S-peptide was synthesized by native chemical ligation of β-annulus-SBz peptid...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-02, Vol.85 (3), p.1668-1673
Main Authors: Matsuura, Kazunori, Ota, Junpei, Fujita, Seiya, Shiomi, Yuriko, Inaba, Hiroshi
Format: Article
Language:English
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Summary:Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of β-annulus-S-peptide and the interaction between S-peptide moiety and S-protein. The β-annulus-S-peptide was synthesized by native chemical ligation of β-annulus-SBz peptide with Cys-containing S-peptide that self-assembled into artificial virus-like capsids of approximately 47 nm in size. Reconstruction of RNase S on the artificial virus-like capsids afforded spherical assembly attached small spheres on the surface, which retained ribonuclease activity.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b02295