Near-infrared light-responsive alginate hydrogels based on diselenide-containing cross-linkage for on demand degradation and drug release

[Display omitted] •Novel near-infrared (NIR) responsive alginate-based hydrogels have been developed.•The hydrogels were click-cross-linked via tetrazine-norbornene chemistry.•Gelation time was only in a few minutes at physiological conditions.•NIR light triggered the de-cross-linking of hydrogels a...

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Bibliographic Details
Published in:Carbohydrate polymers 2019-11, Vol.223, p.115070-115070, Article 115070
Main Authors: Anugrah, Daru Seto Bagus, Ramesh, Kaylan, Kim, Mingeun, Hyun, Kyu, Lim, Kwon Taek
Format: Article
Language:English
Subjects:
Alginate
Alginates - chemical synthesis
Alginates - chemistry
Alginates - radiation effects
Diselenide
Doxorubicin - chemistry
Drug Carriers - chemistry
Drug Carriers - radiation effects
Drug Liberation
Heterocyclic Compounds, 1-Ring - chemical synthesis
Heterocyclic Compounds, 1-Ring - chemistry
Heterocyclic Compounds, 1-Ring - radiation effects
Hydrogel
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogels - radiation effects
Hydrogen Peroxide - chemistry
Infrared Rays
Inverse electron demand diels-alder
NIR-responsive
Norbornanes - chemical synthesis
Norbornanes - chemistry
Norbornanes - radiation effects
Organoselenium Compounds - chemical synthesis
Organoselenium Compounds - chemistry
Organoselenium Compounds - radiation effects
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Summary:[Display omitted] •Novel near-infrared (NIR) responsive alginate-based hydrogels have been developed.•The hydrogels were click-cross-linked via tetrazine-norbornene chemistry.•Gelation time was only in a few minutes at physiological conditions.•NIR light triggered the de-cross-linking of hydrogels and release of loaded DOX.•With the ratio of precursors, we could manipulate the degradation of the hydrogels. A biodegradable, near-infrared (NIR) - responsive hydrogel is one of the most promising strategies as a remotely triggered drug carrier. In this study, novel NIR-responsive hydrogels based on alginate structures were prepared for controllable drug release. The hydrogels were formed rapidly by reacting norbornene-functionalized alginates and tetrazine cross-linkers containing diselenide bonds via inverse electron demand Diels-Alder click chemistry. In order to manipulate their properties, we prepared hydrogels with various cross-linking densities. NIR sensitive indocyanine green (ICG) and a drug, doxorubicin (DOX) were incorporated in the hydrogel matrix during gelation. The hydrogels showed a suppressed release profile under physiological conditions, while NIR light triggered a rapid release of DOX. Under NIR-light irradiation, ICG generated reactive oxygen species which could decompose diselenide bonds in the hydrogel matrix, inducing the gel-sol transition and release of entrapped DOX. The degradation of hydrogels could be also controlled by the ratio of the precursors.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2019.115070