Intermittent cholecalciferol supplementation in children and teenagers followed in pediatric nephrology: data from a prospective single-center single-arm open trial

Vitamin D deficiency is frequent in pediatric nephrology. The 2017 European guidelines recommend keeping 25OH vitamin D (25-D) levels within the 75–120 nmol/L range, ideally with daily supplementation. Intermittent supplementation with D3 has also been proposed. We aimed to assess the influence of o...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pediatrics 2020-04, Vol.179 (4), p.661-669
Main Authors: Aurelle, Manon, Basmaison, Odile, Ranchin, Bruno, Kassai-Koupai, Behrouz, Sellier-Leclerc, Anne-Laure, Bertholet-Thomas, Aurélia, Bacchetta, Justine
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Alkaline phosphatase
Body weight
Calcium (urinary)
Calcium-Regulating Hormones and Agents - administration & dosage
Calciuria
Child
Children
Cholecalciferol - administration & dosage
Creatinine
Dietary supplements
Evolution
Female
Fibroblast growth factor 23
Humans
Hypercalciuria
Kidney diseases
Kidney transplantation
Male
Medicine
Medicine & Public Health
Nephrology
Nephrotic syndrome
Nutrient deficiency
Original Article
Overdose
Parathyroid hormone
Pediatrics
Renal Insufficiency, Chronic - complications
Teenagers
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - etiology
Vitamin deficiency
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vitamin D deficiency is frequent in pediatric nephrology. The 2017 European guidelines recommend keeping 25OH vitamin D (25-D) levels within the 75–120 nmol/L range, ideally with daily supplementation. Intermittent supplementation with D3 has also been proposed. We aimed to assess the influence of our local protocol of intermittent vitamin D supplementation on the evolution of 25-D levels between baseline and 2 months. VITATOL is a prospective single-center study performed in our tertiary unit in children and teenagers followed for chronic kidney disease (CKD), kidney transplantation, or stable chronic nephrotic syndrome with 25-D levels below 75 nmol/L. Intermittent oral cholecalciferol (100,000 IU) was administered depending on baseline vitamin D levels and body weight. The primary outcome was the change in 25-D levels between baseline and 2 months. Secondary outcomes were the evolution of the main mineral biomarkers. Thirty-seven patients were included. Two months after beginning supplementation, corresponding to a median(min-max) of 46 (14–79) days after the last dose of vitamin D, 25-D levels increased from 50 to 76 nmol/L ( p  
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-019-03553-y