Magnetic resonance imaging features of four neonates with total brain injury

Purpose The most severe form of profound asphyxia in neonates is now known as “total brain injury,” which forms part of the clinical spectrum of hypoxic-ischemic encephalopathy (HIE). Although the magnetic resonance (MR) imaging features of total brain injury remain to be determined, a widespread hy...

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Bibliographic Details
Published in:Child's nervous system 2020-06, Vol.36 (6), p.1223-1229
Main Authors: Koshino, Sachiko, Hayakawa, Katsumi, Tanda, Koichi, Morishita, Hiroyuki, Ono, Kohji, Nishimura, Akira, Koshino, Katsuhiro, Yamada, Kei
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Neurosciences
Neurosurgery
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Summary:Purpose The most severe form of profound asphyxia in neonates is now known as “total brain injury,” which forms part of the clinical spectrum of hypoxic-ischemic encephalopathy (HIE). Although the magnetic resonance (MR) imaging features of total brain injury remain to be determined, a widespread hyperintensity of the supratentorial brain, known as the “white cerebrum sign,” has been reported in diffusion-weighted images (DWI). Methods We examined four neonates who developed severe profound asphyxia. Results In the first week of life, all neonates showed the white cerebrum sign on DWI. A follow-up of these cases over a period of 1 month revealed diffuse bilateral multicystic encephalomalacia (MCE) as well as shrinkage of the basal ganglia and thalami (BG/T). These MR findings were common to all neonates, and all the neonates had severe adverse clinical outcomes. Conclusion Neonates, who exhibit the white cerebrum sign on MR imaging due to profound asphyxia, develop major disabilities, and MCE with shrinkage of the BG/T suggests miserable outcomes.
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-019-04457-w