Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment

In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria‐targeted zinc‐doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2020-01, Vol.16 (3), p.e1905424-n/a
Main Authors: Chen, Mengwei, Wu, Jiaojiao, Ning, Peng, Wang, Jingjing, Ma, Zuan, Huang, Liqun, Plaza, Gustavo R., Shen, Yajing, Xu, Chang, Han, Yu, Lesniak, Maciej S., Liu, Zhongmin, Cheng, Yu
Format: Article
Language:English
Subjects:
apoptosis
Brain cancer
Brain damage
Cancer
Cell Line, Tumor
Cell Lineage
Humans
In vivo methods and tests
Iron oxides
magnetic nanocubes
Magnetics
magnetomechanical destruction
Mechanical Phenomena
Mitochondria
Mitochondria - metabolism
mitochondrial
Nanotechnology
Neoplasms - pathology
Neoplasms - therapy
Remote control
Tumors
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Summary:In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria‐targeted zinc‐doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep‐seated tumors in a spatiotemporal fashion. The 20 nm nanocube with mitochondrial‐targeting properties is designed for efficient cancer destruction. Under a rotating magnetic field (RMF) at 15 Hz and 40 mT, it works as a spinner applying the magnetomechanical destruction to the mitochondria of cancer cells. Both in vitro and in vivo studies show that the nanospinners can destroy the cancer cells and inhibit the tumor growth.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201905424