Utility of dual-energy CT for predicting the vascularity of meningiomas

•DECT parameters could predict the vascular density of meningiomas.•Radiation exposure of DECT was much lower than that of PCT.•DECT potentially could replace PCT for evaluating vascularity of meningiomas. Dual-energy computed tomography (DECT) can provide iodine, electron density (ED), and effectiv...

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Published in:European journal of radiology 2020-02, Vol.123, p.108790-108790, Article 108790
Main Authors: Onishi, Shumpei, Fujioka, Chikako, Kaichi, Yoko, Amatya, Vishwa Jeet, Ishifuro, Minoru, Takeshima, Yukio, Awai, Kazuo, Sugiyama, Kazuhiko, Kurisu, Kaoru, Yamasaki, Fumiyuki
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Dual-energy CT
Female
Humans
Male
Meningeal Neoplasms - blood supply
Meningeal Neoplasms - diagnostic imaging
Meningioma
Meningioma - blood supply
Meningioma - diagnostic imaging
Middle Aged
Multidetector computed tomography
Perfusion
Radiography, Dual-Energy Scanned Projection - methods
Retrospective Studies
Tomography, X-Ray Computed - instrumentation
Tomography, X-Ray Computed - methods
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Summary:•DECT parameters could predict the vascular density of meningiomas.•Radiation exposure of DECT was much lower than that of PCT.•DECT potentially could replace PCT for evaluating vascularity of meningiomas. Dual-energy computed tomography (DECT) can provide iodine, electron density (ED), and effective atomic number Z (Zeff) maps, facilitating the identification of tissue types. We investigated whether DECT parameters can predict the vascularity of meningiomas. We acquired DECT and perfusion CT (PCT) images in 24 patients with histologically diagnosed meningioma. Regions of interest (ROIs) were placed at the tumor in iodine, ED, and Zeff maps derived from DECT and in a blood volume (BV) map derived from PCT. To normalize these parameters' values, we divided them by the values of contralateral normal-appearing white matter, i.e., the relative (r)ED, rZeff, and rBV. The vascular density of the tumor specimens was immunohistochemically analyzed by calculating the von Willebrand factor-positive vessel wall. We calculated Pearson's correlation coefficients to determine the correlation with PCT/DECT parameters and an immunohistopathological index. Contrast rZeff (r = 0.7020, p = 0.0001) and iodine (r = 0.5814, p = 0.0029) both had positive correlations with rBV derived from PCT. The rED values were negatively correlated with the rBV values (r = −0.4735, p = 0.0194), and the vascular density results confirmed positive correlations with rBV (r = 0.6909, p = 0.0002) and contrast rZeff (r = 0.4982, p = 0.0132) and a negative correlation with rED (r = −0.4265, p = 0.0377). Regarding the radiation exposure, the mean estimated volume CT dose index (CTDIvol) of DECT was 33.1 ± 1.72 mGy, much lower than that of PCT (103.3 ± 4.65 mGy). DECT predicted vascular density with lower radiation exposure compared to PCT. DECT could potentially replace PCT for evaluating the vascularity of meningiomas.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2019.108790