Porous silicon nanomaterials: recent advances in surface engineering for controlled drug-delivery applications

Porous silicon (pSi) nanomaterials are increasingly attractive for biomedical applications due to their promising properties such as simple and feasible fabrication procedures, tunable morphology, versatile surface modification routes, biocompatibility and biodegradability. This review focuses on re...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2019-12, Vol.14 (24), p.3213-3230
Main Authors: Zhang, De-Xiang, Esser, Lars, Vasani, Roshan B, Thissen, Helmut, Voelcker, Nicolas H
Format: Article
Language:English
Subjects:
Acids
active targeting
application
Copyright
drug delivery
Electrolytes
Etching
Nanomaterials
Nanoparticles
Polymers
Pore size
porous silicon
pSi-polymer hybrids
Quantum dots
Scanning electron microscopy
Silicon wafers
stealth coating
stimuli-responsive
surface modification
Transmission electron microscopy
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Summary:Porous silicon (pSi) nanomaterials are increasingly attractive for biomedical applications due to their promising properties such as simple and feasible fabrication procedures, tunable morphology, versatile surface modification routes, biocompatibility and biodegradability. This review focuses on recent advances in surface modification of pSi for controlled drug delivery applications. A range of functionalization strategies and fabrication methods for pSi-polymer hybrids are summarized. Surface engineering solutions such as stimuli-responsive polymer grafting, stealth coatings and active targeting modifications are highlighted as examples to demonstrate what can be achieved. Finally, the current status of engineered pSi nanomaterials for applications is reviewed and future prospects and challenges in drug-delivery applications are discussed.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2019-0167