Exercise Intensity and Recovery on Circulating Brain-derived Neurotrophic Factor

INTRODUCTIONBrain-derived neurotrophic factor (BDNF) is an exercise-induced neurotropin mediating neuroprotection and synaptic plasticity. Although exercise intensity is implicated as a potentially important mediator of BNDF release after exercise, the optimal exercise stimulus (interval vs continuo...

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Published in:Medicine and science in sports and exercise 2020-05, Vol.52 (5), p.1210-1217
Main Authors: REYCRAFT, JOSHUA T, ISLAM, HASHIM, TOWNSEND, LOGAN K, HAYWARD, GRANT C, HAZELL, TOM J, MACPHERSON, REBECCA E K
Format: Article
Language:English
Subjects:
Adult
Brain-Derived Neurotrophic Factor - blood
Exercise - physiology
Fibronectins - blood
High-Intensity Interval Training
Humans
Lactic Acid - blood
Male
Neuronal Plasticity - physiology
Neuroprotection - physiology
Physical Conditioning, Human - physiology
Young Adult
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Summary:INTRODUCTIONBrain-derived neurotrophic factor (BDNF) is an exercise-induced neurotropin mediating neuroprotection and synaptic plasticity. Although exercise intensity is implicated as a potentially important mediator of BNDF release after exercise, the optimal exercise stimulus (interval vs continuous) and intensity (submaximal vs supramaximal) for augmenting circulating BDNF levels remains unknown. Irisin, an exercise-driven myokine, may also contribute to neuroprotection by upregulating BDNF. PURPOSETo examine the response and recovery of plasma BDNF and irisin after acute exercise of differing intensities. METHODSEight males (23.1 ± 3.0 yr of age; V˙O2max 51.2 ± 4.4 mL·kg·min) completed four acute exercise sessions1) moderate-intensity continuous training (MICT, 65% V˙O2max); 2) vigorous-intensity continuous training (VICT, 85% V˙O2max); 3) sprint interval training (SIT, “all out”); and 4) no exercise (CTRL). Blood was collected preexercise as well as immediately, 30 min, and 90 min postexercise. Plasma BDNF and irisin were assessed with commercially available enzyme-linked immunosorbent assay kits. RESULTSPlasma BDNF levels increased immediately after exercise in the SIT group (P < 0.0001) with plasma concentrations recovering 30 and 90 min postexercise. The BDNF levels after MICT were reduced 30 min postexercise compared with immediately postexercise (P = 0.0189), with no other changes across time points in MICT and VICT groups. Plasma BDNF area under the curve in SIT was significantly higher compared with CTRL, MICT, and VICT (P = 0.0020). No changes in plasma irisin across exercise groups and time points were found (P > 0.9999). CONCLUSIONSPlasma BDNF levels increased in an intensity-dependent manner with SIT eliciting the highest BDNF concentration immediately postexercise. These results identify SIT as a time-efficient exercise modality to promote brain health through BDNF release.
ISSN:0195-9131
1530-0315
DOI:10.1249/MSS.0000000000002242