Clinicopathologic risk factors of radioactive iodine therapy based on response assessment in patients with differentiated thyroid cancer: a multicenter retrospective cohort study

Purpose We investigated whether predictive clinicopathologic factors can be affected by different response criteria and how the clinical usefulness of radioactive iodine (RAI) therapy should be evaluated considering variable factors in patients with differentiated thyroid carcinoma (DTC). Methods A...

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Published in:European journal of nuclear medicine and molecular imaging 2020-03, Vol.47 (3), p.561-571
Main Authors: Kwon, Seong Young, Lee, Sang-Woo, Kong, Eun Jung, Kim, Keunyoung, Kim, Byung Il, Kim, Jahae, Kim, Heeyoung, Park, Seol Hoon, Park, Jisun, Park, Hye Lim, Oh, So Won, Won, Kyoung Sook, Ryu, Young Hoon, Yoon, Joon-Kee, Lee, Soo Jin, Lee, Jong Jin, Chong, Ari, Jeong, Young Jin, Jeong, Ju Hye, Cho, Young Seok, Cho, Arthur, Cheon, Gi Jeong, Choi, Eun Kyoung, Hwang, Jae Pil, Bae, Sang Kyun
Format: Article
Language:English
Subjects:
Cancer
Cardiology
Classification
Cohort analysis
Criteria
Endocrinology
Evaluation
Humans
Imaging
Iodine
Iodine 131
Iodine Radioisotopes - therapeutic use
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Original Article
Orthopedics
Patients
Predictions
Radiology
Regression analysis
Retrospective Studies
Risk analysis
Risk Factors
Therapy
Thyroglobulin
Thyroid cancer
Thyroid carcinoma
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - radiotherapy
Thyroid Neoplasms - surgery
Thyroid-stimulating hormone
Thyroidectomy
Ultrasound
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Summary:Purpose We investigated whether predictive clinicopathologic factors can be affected by different response criteria and how the clinical usefulness of radioactive iodine (RAI) therapy should be evaluated considering variable factors in patients with differentiated thyroid carcinoma (DTC). Methods A total of 1563 patients with DTC who underwent first RAI therapy after total or near total thyroidectomy were retrospectively enrolled from 25 hospitals. Response to therapy was evaluated with two different protocols based on combination of biochemical and imaging studies: (1) serum thyroglobulin (Tg) and neck ultrasonography (US) and (2) serum Tg, neck US, and radioiodine scan. The responses to therapy were classified into excellent and non-excellent or acceptable and non-acceptable to minimize the effect of non-specific imaging findings. We investigated which factors were associated with response to therapy depending on the follow-up protocols as well as response classifications. Multivariate logistic regression analysis was performed to identify factors significantly predicting response to therapy. Results The proportion of patients in the excellent response group significantly decreased from 76.5 to 59.6% when radioiodine scan was added to the follow-up protocol ( P  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-019-04634-8