Hereditary hemochromatosis is associated with increased use of joint replacement surgery: Results of a nationwide analysis

Hereditary hemochromatosis (HH) may lead to iron deposition–mediated arthropathy, causing progressive joint degeneration, necessitating replacement arthroplasty. Studies have noted an increased need for replacement arthroplasty in patients with HH. We aimed to compare the use of replacement arthropl...

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Bibliographic Details
Published in:Seminars in arthritis and rheumatism 2020-04, Vol.50 (2), p.360-365
Main Authors: Kröner, Paul T., Mareth, Karl F., Wijarnpreecha, Karn, Palmer, William C.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arthroplasty, Replacement - statistics & numerical data
Case-Control Studies
Databases, Factual
Disease Progression
Female
Hemochromatosis - epidemiology
Hemochromatosis - surgery
Hereditary hemochromatosis
Humans
Inpatient outcomes
Male
Middle Aged
National (Nationwide) inpatient sample
Replacement arthroplasty
Retrospective Studies
Risk Factors
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Summary:Hereditary hemochromatosis (HH) may lead to iron deposition–mediated arthropathy, causing progressive joint degeneration, necessitating replacement arthroplasty. Studies have noted an increased need for replacement arthroplasty in patients with HH. We aimed to compare the use of replacement arthroplasty and inpatient economic burden in patients with and without HH. For our retrospective cohort study, we used the 2014 Nationwide Inpatient Sample. Patients with an International Classification of Diseases, Ninth Revision code for HH were included. The primary outcome was use of replacement arthroplasty; secondary outcomes were hospital length of stay, hospital costs, and total hospitalization charges. Multivariate logistic regression yielded confounder-adjusted odds ratios (ORs) and means. Of 18,250 patients with HH, 7,483 (41.0%) were women and 1,155 (6.3%) underwent replacement arthroplasty. Mean (SD) age for patients with HH and arthroplasty was 66 (18) years. The percentage of patients with HH who underwent replacement arthroplasty was higher than those without HH (3.4%; P
ISSN:0049-0172
1532-866X
DOI:10.1016/j.semarthrit.2019.10.003