Modeling the release of curcumin from microparticles of poly(hydroxybutyrate) [PHB]

Polyhydroxybutyrate (PHB) is biodegradable and biocompatible polyester that has been recently used for developing different drug delivery systems (DDS). Microspheres as DDS, consist of a polymeric matrix with a diameter of 1–125 μm which contains a substance entrapped, and then released mainly throu...

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Bibliographic Details
Published in:International journal of biological macromolecules 2020-02, Vol.144, p.47-52
Main Authors: Aguilar-Rabiela, Arturo Elias, Hernández-Cooper, Ernesto Manuel, Otero, José Antonio, Vergara-Porras, Berenice
Format: Article
Language:English
Subjects:
Curcumin diffusion
Modeling
Polyhydroxybutyrate
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Summary:Polyhydroxybutyrate (PHB) is biodegradable and biocompatible polyester that has been recently used for developing different drug delivery systems (DDS). Microspheres as DDS, consist of a polymeric matrix with a diameter of 1–125 μm which contains a substance entrapped, and then released mainly through diffusion. In order to make DDS viable for commercial applications, it is essential to develop models that describe and predict the substance release kinetic. In this study, microspheres of PHB with curcumin entrapped were synthesized; the release of curcumin was studied and modeled. As a first approach, a physical model was introduced, in which mass transference was considered analogous to heat transference. The proposed model was based on local mass balance through the classical diffusion equation and total mass balance imposed through an integro-differential equation. The total mass balance introduced nonlinearities in the dynamics of the drug within the fluid; therefore, a semi-analytical approach based on the heat balance integral method was applied to solve the proposed model. Finally, by using the experimental rate of release of curcumin, the semi-analytical solutions to the proposed model were compared with the experimental release data, showing the importance of adding mass balance in the nonlinear mathematical model in order to describe more accurately the release kinetics. •Diffusion kinetic release can be better described by considering the mass balance into the mathematical model•The kinetic release through biopolymer microspheres nneeds to be explored using novel approaches.•Diffusion kinetic release of a model drug can be better described by considering the balance of mass into the mathematical model.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2019.11.242