Increasing insulin resistance predicts adverse pregnancy outcomes in women with gestational diabetes mellitus

Background This study aimed to investigate the association between maternal insulin resistance (IR) in the late second trimester and pregnancy outcomes, as well as to identify risk factors of IR among women with gestational diabetes mellitus (GDM). Methods A retrospective study was conducted among 2...

Full description

Saved in:
Bibliographic Details
Published in:Journal of diabetes 2020-06, Vol.12 (6), p.438-446
Main Authors: Sun, Yi‐Ying, Juan, Juan, Xu, Qian‐Qian, Su, Ri‐Na, Hirst, Jane E., Yang, Hui‐Xia
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
Body Mass Index
Diabetes
Diabetes, Gestational - metabolism
Female
Fetal Macrosomia - etiology
Fetal Macrosomia - metabolism
Gestational diabetes
gestational diabetes mellitus
Health risk assessment
Homeostasis
Humans
Insulin - blood
Insulin resistance
Insulin Resistance - physiology
Pregnancy
Pregnancy Outcome
pregnancy outcomes
Premature Birth - etiology
Premature Birth - metabolism
Retrospective Studies
Risk Factors
Womens health
妊娠期糖尿病
妊娠结局
胰岛素抵抗
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background This study aimed to investigate the association between maternal insulin resistance (IR) in the late second trimester and pregnancy outcomes, as well as to identify risk factors of IR among women with gestational diabetes mellitus (GDM). Methods A retrospective study was conducted among 2647 women diagnosed with GDM. IR was evaluated using the homeostasis model assessment method for IR (HOMA‐IR) in the late second trimester (between 24 and 28 weeks), and the lipid profiles were measured at the same time. Patients were divided into groups based on quartiles of HOMA‐IR. The information on pregnancy outcomes and risk factors was extracted from the medical records of all participants and entered electronically. Logistic regression models were used to analyze the associations between HOMA‐IR and pregnancy outcomes, as well as the associations between risk factors and HOMA‐IR. Results Greater IR was associated with cesarean delivery, preterm delivery, macrosomia, and large for gestational age newborns, but only significantly associated with preterm delivery after adjustment for potential confounders (P 
ISSN:1753-0393
1753-0407
DOI:10.1111/1753-0407.13013