Estimation of heritability and familial correlation in myopia is not affected by past sun exposure

: To consider the effect of including past sun exposure in estimating heritability and familial correlation of myopia-related traits. : We calculate familial correlation and heritability of anterior chamber depth (ACD), axial length (AL), corneal curvature (CC), and spherical equivalent (SphE), with...

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Bibliographic Details
Published in:Ophthalmic genetics 2019-11, Vol.40 (6), p.500-506
Main Authors: Charng, Jason, Sanfilippo, Paul G, Lingham, Gareth, Stevenson, Louis J, Mackey, David A, Yazar, Seyhan
Format: Article
Language:English
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Summary:: To consider the effect of including past sun exposure in estimating heritability and familial correlation of myopia-related traits. : We calculate familial correlation and heritability of anterior chamber depth (ACD), axial length (AL), corneal curvature (CC), and spherical equivalent (SphE), with or without past sun exposure as a covariate, in a large number of unrelated nuclear families from the Raine Study (parents: Gen1, offspring: Gen2) residing in Perth, Australia, a city with a high amount of daily sunlight. Past sun exposure was objectively measured using conjunctival ultraviolet autofluorescence (CUVAF) photography. : When sun exposure was not included in the analysis, both familial correlation (correlation±SE; ACD: 0.308 ± 0.065, AL: 0.374 ± 0.061, CC: 0.436 ± 0.063, SphE: 0.281 ± 0.070) and heritability (ACD: 0.606 ± 0.104, AL: 0.623 ± 0.098, CC: 0.793 ± 0.079, SphE: 0.591 ± 0.106) were significant for all traits (all < .001). However, there was no significant change in both familial correlation and heritability estimates when sun exposure was included as an additional covariate. : Past sun exposure does not affect the estimation of the additive genetic component in myopia-related traits.
ISSN:1381-6810
1744-5094
DOI:10.1080/13816810.2019.1696376