Shotgun lipidomics-based characterization of the landscape of lipid metabolism in colorectal cancer

Solid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma lipid composition suggested a role for metabolic reprogramming in colorectal cancer (CRC) development. However, a conclusive picture of CRC-ass...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular and cell biology of lipids 2020-03, Vol.1865 (3), p.158579-158579, Article 158579
Main Authors: Wang, Yuting, Hinz, Sebastian, Uckermann, Ortrud, Hönscheid, Pia, von Schönfels, Witigo, Burmeister, Greta, Hendricks, Alexander, Ackerman, Jacobo Miranda, Baretton, Gustavo B., Hampe, Jochen, Brosch, Mario, Schafmayer, Clemens, Shevchenko, Andrej, Zeissig, Sebastian
Format: Article
Language:English
Subjects:
Cancer
Colon
Lipid metabolism
Mass spectrometry
Shotgun lipidomics
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Summary:Solid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma lipid composition suggested a role for metabolic reprogramming in colorectal cancer (CRC) development. However, a conclusive picture of CRC-associated lipidome alterations in the tumor tissue has not emerged. Here, we determined molar abundances of 342 species from 20 lipid classes in matched biopsies of CRC and adjacent normal mucosa. We demonstrate that in contrast to previous reports, CRC shows a largely preserved lipidome composition that resembles that of normal colonic mucosa. Important exceptions include increased levels of lyso-phosphatidylinositols in CRC and reduced abundance of ether phospholipids in advanced stages of CRC. As such, our observations challenge the concept of widespread alterations in lipid metabolism in CRC and rather suggest changes in the cellular lipid profile that are limited to selected lipids involved in signaling and the scavenging of reactive oxygen species. •We provide comprehensive, quantitative lipidomics of colorectal cancer (CRC) tissue.•The lipidome of CRC largely resembles that of normal mucosa.•Changes in lipid abundance are limited to few lyso-phospholipids and ether lipids.•Our results do not support the notion of global lipidome alterations in CRC.
ISSN:1388-1981
1879-2618
DOI:10.1016/j.bbalip.2019.158579