RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous Malformations

BACKGROUND AND PURPOSE—Interventional treatment of unruptured brain arteriovenous malformations (BAVMs) has become increasingly controversial. Because medical therapy is still lacking, we aimed to obtain insight into the disease mechanisms implicated in BAVMs and to identify potential targets for me...

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Bibliographic Details
Published in:Stroke (1970) 2020-01, Vol.51 (1), p.268-274
Main Authors: Hauer, Allard J, Kleinloog, Rachel, Giuliani, Fabrizio, Rinkel, Gabriël J.E, de Kort, Gerard A, Berkelbach van der Sprenkel, Jan Willem, van der Zwan, Albert, Gosselaar, Peter H, van Rijen, Peter C, de Boer-Bergsma, Jelkje J, Deelen, Patrick, Swertz, Morris A, De Muynck, Louis, Van Damme, Philip, Veldink, Jan H, Ruigrok, Ynte M, Klijn, Catharina J.M
Format: Article
Language:English
Subjects:
Adult
Aged
Brain - metabolism
Female
Gene Expression Regulation
High-Throughput Nucleotide Sequencing
Humans
Inflammation - genetics
Inflammation - metabolism
Inflammation - pathology
Intracranial Arteriovenous Malformations - genetics
Intracranial Arteriovenous Malformations - metabolism
Intracranial Arteriovenous Malformations - pathology
Male
Middle Aged
Retrospective Studies
Sequence Analysis, RNA
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Summary:BACKGROUND AND PURPOSE—Interventional treatment of unruptured brain arteriovenous malformations (BAVMs) has become increasingly controversial. Because medical therapy is still lacking, we aimed to obtain insight into the disease mechanisms implicated in BAVMs and to identify potential targets for medical treatment to prevent rupture of a BAVM. METHODS—We used next-generation RNA sequencing to identify differential expression on a transcriptome-wide level comparing tissue samples of 12 BAVMs to 16 intracranial control arteries. We identified differentially expressed genes by negative binominal generalized log-linear regression (false discovery rate corrected P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.119.025657