Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome

Alteration of nutritional habits play an essential role on the risk of developing Metabolic Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of foods included in the Mediterranean diet (MetDiet) pattern like, such as olive oil, nuts, fruit, fiber, vegetables, wine...

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Published in:European journal of medicinal chemistry 2020-01, Vol.186, p.111903-111903, Article 111903
Main Authors: Bagetta, Donatella, Maruca, Annalisa, Lupia, Antonio, Mesiti, Francesco, Catalano, Raffaella, Romeo, Isabella, Moraca, Federica, Ambrosio, Francesca Alessandra, Costa, Giosuè, Artese, Anna, Ortuso, Francesco, Alcaro, Stefano, Rocca, Roberta
Format: Article
Language:English
Subjects:
Anti-inflammatory
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Anti-oxidant
Antioxidants - chemistry
Antioxidants - therapeutic use
Diet, Mediterranean
Dose-Response Relationship, Drug
Humans
Mediterranean diet (MedDiet)
Metabolic syndrome (MetS)
Metabolic Syndrome - drug therapy
Metabolic Syndrome - metabolism
Molecular Structure
Multi-target
Phytochemicals - chemistry
Phytochemicals - therapeutic use
Polypharmacology
Polyphenols
Prevention
Protective Agents - chemistry
Protective Agents - therapeutic use
Structure-Activity Relationship
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Summary:Alteration of nutritional habits play an essential role on the risk of developing Metabolic Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of foods included in the Mediterranean diet (MetDiet) pattern like, such as olive oil, nuts, fruit, fiber, vegetables, wine and grain cereals has protective effects on the different risk factors characterizing the MetS. The beneficial effects of the MetDiet in the MetS are mainly due to the antioxidant and anti-inflammatory properties of the most abundant phytochemical components of such foods as polyphenols like resveratrol and oleuropein, allyl sulfides, ellagic acid, mono- and poly-unsaturated fatty acids (MUFA and PUFA), tocopherols and flavonoids like quercetin, which have shown positive results in the prevention of cardiovascular diseases (CVDs), with related risk factors, like hypertension, hypercholesterolemia and obesity. In this review, we highlighted the multi-target activities of the bioactive components contained in some foods typical of the Mediterranean area like olive oil, onion, liquorice, rosemary, oregano, hazelnut, pistachio, “Melannurca” apple, red wine, hot pepper, Citrus sp. fruits, saffron and garlic, with particular focus on their impact on health outcomes in relation to MetS main key factors, such as insulin resistance (IR) and type 2 diabetes mellitus (T2DM), endothelial dysfunctions, inflammatory response, oxidative stress and dyslipidaemic and hypercholesterolemic effects. [Display omitted] •Metabolic syndrome (MetS) increases the risk of heart diseases and type 2 diabetes.•Beneficial effects of Mediterranean diet (MetDiet) products were proved against MetS.•This review focuses on the MetDiet phytochemicals targeting multiple MetS pathways.•MetDiet products could represent a resource in the treatment and prevention of MetS.
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2019.111903