Cellular cross-talks in the diseased and aging heart

Communication between cells is an important, evolutionarily conserved mechanism which enables the coordinated function of multicellular organisms. Heterogeneity within cell populations drive a remarkable network of cellular cross-talk that allows the heart to function as an integrated unit with dist...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2020-01, Vol.138, p.136-146
Main Authors: Wagner, Julian U.G., Dimmeler, Stefanie
Format: Article
Language:English
Subjects:
Aging - pathology
Animals
Cells - metabolism
Humans
Inflammation - pathology
Myocardium - pathology
Regeneration
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Summary:Communication between cells is an important, evolutionarily conserved mechanism which enables the coordinated function of multicellular organisms. Heterogeneity within cell populations drive a remarkable network of cellular cross-talk that allows the heart to function as an integrated unit with distinct tasks allocated to sub-specialized cells. During diseases and aging, cells acquire an overt disordered state that significantly contributes to an altered cellular cross-talk and hence drive cardiac remodeling processes and cardiovascular diseases. However, adaptive mechanisms, and phenotypic changes in subpopulations of cells (e.g. reparative macrophages or fibroblasts) can also contribute to repair and regeneration. In this article, we review the cellular cross-talks between immune cells, endothelial cells, fibroblasts and cardiomyocytes that control heart failure by contributing to cardiac dysfunction and aging, or by mediating repair and regeneration of the heart after injury.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2019.11.152