C-peptide concentrations in patients with type 2 diabetes treated with insulin

To determine beta cell reserves of patients with type 2 diabetes who are treated with insulin by using fasting C-peptide concentrations and to investigate the clinical features related to C-peptide concentrations. Patients with type 2 diabetes, who were using insulin as monotherapy or in combination...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2019-11, Vol.13 (6), p.3099-3104
Main Authors: Uzunlulu, Mehmet, Oguz, Aytekin, Arslan Bahadir, Müzeyyen, Erbakan, Ayse Naciye, Vural Keskinler, Mirac, Alpaslan Mesci, Banu
Format: Article
Language:English
Subjects:
Aged
Beta-cell reserve
Blood Glucose - analysis
C-peptide
C-Peptide - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Female
Glycated Hemoglobin A - analysis
Humans
Insulin - therapeutic use
Insulin use
Insulin-Secreting Cells - physiology
Lipids - blood
Male
Middle Aged
Prospective Studies
Type 2 diabetes
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Summary:To determine beta cell reserves of patients with type 2 diabetes who are treated with insulin by using fasting C-peptide concentrations and to investigate the clinical features related to C-peptide concentrations. Patients with type 2 diabetes, who were using insulin as monotherapy or in combination therapy, were divided into three groups; those with an insufficient beta cell reserve (C-peptide: 2 ng/mL). In the 249 patients (mean age, 61.77 ± 9.34 years; 40.6% male), the mean duration of diabetes was 13.9 ± 8.43 years. The mean HbA1c concentrations, fasting glucose and C-peptide concentrations were 8.88 ± 1.87%, 184.29 ± 77.88 mg/dL and 1.95 ± 1.37 ng/mL, respectively. Fifty-seven percent of patients (n = 142) had a borderline beta cell reserve and 37% (n = 92) had high C-peptide concentrations. Only 6% of patients (n = 15) had an insufficient beta cell reserve. C-peptide levels were positively correlated with waist circumference (r: 0.282; p = 0.001), hip circumference (r: 0.251; p = 0.001), body mass index (r: 0.279; p = 0.001), fasting glucose concentrations (r: 0.309; p = 0.001) and triglyceride concentrations (r: 0.358; p = 0.001). In this study, almost all patients with type 2 diabetes using insulin were found to have sufficient or borderline beta cell reserves and insulin resistance-related parameters were prominent in those with adequate beta cell reserve. NCT04005261
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2019.11.010