Cobalt Single‐Atom‐Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity

The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long‐standing pursuit in chemical synthesis. A vertically structured, cobalt single atom‐intercalated molybdenum disulfide catalyst (Co1‐in‐MoS2) is developed for the chemoselective transfo...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2020-01, Vol.32 (4), p.e1906437-n/a
Main Authors: Chen, Zhongxin, Liu, Cuibo, Liu, Jia, Li, Jing, Xi, Shibo, Chi, Xiao, Xu, Haisen, Park, In‐Hyeok, Peng, Xinwen, Li, Xing, Yu, Wei, Liu, Xiaowang, Zhong, Linxin, Leng, Kai, Huang, Wei, Koh, Ming Joo, Loh, Kian Ping
Format: Article
Language:English
Subjects:
Aldehydes
Alkenes
Alkynes
Amines
Catalysts
Chemical synthesis
chemoselective transformation
Cobalt
Derivatives
electrochemical intercalation
Electronic structure
Esters
Fine chemicals
Ketones
Materials science
Molybdenum
Molybdenum disulfide
organic catalysis
Organic chemistry
Oxidation
single‐atom materials
Substrates
Sulfones
transition metal dichalcogenides
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Summary:The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long‐standing pursuit in chemical synthesis. A vertically structured, cobalt single atom‐intercalated molybdenum disulfide catalyst (Co1‐in‐MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single‐atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide‐bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high‐value, multifunctional sulfones and late‐stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom‐intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions. A vertically structured, cobalt single‐atom‐intercalated MoS2 catalyst (Co1‐in‐MoS2) is developed for the chemoselective oxidation of sulfides to produce 34 high‐value, multifunctional sulfone derivatives and late‐stage functionalization of pharmaceuticals (Tamiflu).
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201906437