Low-Grade Ductal Carcinoma In Situ

Abstract Objectives We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system. Methods Three expert b...

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Bibliographic Details
Published in:American journal of clinical pathology 2020-02, Vol.153 (3), p.360-367
Main Authors: Alghamdi, Sarah A, Krishnamurthy, Kritika, Garces Narvaez, Sofia A, Algashaamy, Khaled J, Aoun, Jessica, Reis, Isildinha M, Recine, Monica A, Jorda, Merce, Poppiti, Robert J, Gomez-Fernandez, Carmen R
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast - pathology
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Carcinoma, Intraductal, Noninfiltrating - diagnosis
Carcinoma, Intraductal, Noninfiltrating - pathology
Female
Humans
Male
Middle Aged
Neoplasm Grading
Observer Variation
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Summary:Abstract Objectives We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system. Methods Three expert breast pathologists and one junior pathologist identified low-grade DCIS from a set of 300 DCIS slides. Months later, participants were asked to grade the 300 cases using the standard three-tiered system. Results Using the two-tiered system, interobserver agreement among breast pathologists was considered moderate (κ = 0.575). The agreement was similar (κ = 0.532) with the junior pathologist included. Using the three-tiered system, pathologists’ agreement was poor (κ = 0.235). Conclusions Pathologists’ reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance.
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqz179