Synergistic Pd/Cu Catalysis in Organic Synthesis

Synergistic Pd/Cu catalysis has been utilized in the Sonogashira reaction since 1975. However, this strategy has not received much attention from the organic chemist community until recently. Synergistic Pd/Cu catalysis is becoming a proficient method for the development of catalytic reactions, incl...

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Bibliographic Details
Published in:Chemistry : a European journal 2020-04, Vol.26 (22), p.4895-4916
Main Authors: Wu, Yue, Huo, Xiaohong, Zhang, Wanbin
Format: Article
Language:English
Subjects:
bimetallic catalysis
Catalysis
Catalysts
Chemical reactions
Chemical synthesis
Chemistry
Copper
Cross coupling
Palladium
Reaction mechanisms
Sonogashira reaction
stereodivergent synthesis
synergistic Pd/Cu catalysis
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Summary:Synergistic Pd/Cu catalysis has been utilized in the Sonogashira reaction since 1975. However, this strategy has not received much attention from the organic chemist community until recently. Synergistic Pd/Cu catalysis is becoming a proficient method for the development of catalytic reactions, including several new and efficient cross‐coupling reactions. Additionally, several challenging asymmetric reactions, including stereodivergent synthesis, have been discovered by the combined use of a chiral metal catalyst and a second achiral metal catalyst or two chiral metal catalysts. This review provides an overview of this field, with the aims of highlighting both the development of synergistic Pd/Cu catalysis in organic synthesis and the reaction mechanisms involved in this research area. Synergistic Pd/Cu catalysis is becoming a proficient method for the development of catalytic reactions, including several new and efficient cross‐coupling reactions. Additionally, several challenging asymmetric reactions, including stereodivergent synthesis, have been discovered by the combined use of a chiral metal catalyst and a second achiral metal catalyst or two chiral metal catalysts.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201904495