Clinical effect of the SCMC APL-2010 regimen in treatment of acute promyelocytic leukemia in children: an analysis of 44 cases

To study the clinical effect of the SCMC APL-2010 regimen in the treatment of acute promyelocytic leukemia (APL) in children. A retrospective analysis was performed for the clinical data of 44 children with APL who received treatment with the SCMC APL-2010 regimen between April 2010 and July 2016. T...

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Published in:Zhongguo dang dai er ke za zhi 2019-11, Vol.21 (11), p.1073
Main Authors: Wang, Zhuo, Shen, Shu-Hong, Tang, Yan-Jing, Xue, Hui-Liang, Hu, Wen-Ting, Pan, Ci, Tang, Jing-Yan, Gu, Long-Jun, Chen, Jing
Format: Article
Language:Chinese
Subjects:
Antineoplastic Combined Chemotherapy Protocols
Child
Disease-Free Survival
Humans
Leukemia, Promyelocytic, Acute
Male
Remission Induction
Retrospective Studies
Treatment Outcome
Tretinoin
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Summary:To study the clinical effect of the SCMC APL-2010 regimen in the treatment of acute promyelocytic leukemia (APL) in children. A retrospective analysis was performed for the clinical data of 44 children with APL who received treatment with the SCMC APL-2010 regimen between April 2010 and July 2016. The Kaplan-Meier survival analysis was used to evaluate event-free survival (EFS) rate and overall survival (OS) rate. Of the 44 children with APL, 42 (95%) achieved a complete remission (CR) after one course of treatment and 1 achieved CR after two courses of treatment, with an overall CR rate of 98%. The 9-year EFS and OS rates were 96%±3% and 97.7%±2.2% respectively. As for adverse events, 41 (93%) had infection, 29 (66%) had granulocyte reduction, 12 (27%, 1 died) had differentiation syndrome, 16 (36%) had liver dysfunction, 12 (27%) had adverse gastrointestinal reactions, and 7 (16%) had QT prolongation, 1 (2%) had orchitis, and no secondary neoplasm was observed. Children with APL receiving the SCMC APL-2010 r
ISSN:1008-8830
DOI:10.7499/j.issn.1008-8830.2019.11.004