Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility: A Systematic Review and Meta-Analysis

This meta-analysis was carried out to evaluate the associations between IL-10 polymorphisms and Kawasaki disease (KD) risk. A comprehensive literature search was performed using PubMed, EMBASE, China National Knowledge Infrastructure and SciELO for all relevant studies evaluating IL-10 polymorphism...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2021-04, Vol.40 (2), p.153-165
Main Authors: Ferdosian, Farzad, Dastgheib, Seyed Alireza, Morovati-Sharifabad, Majid, Lookzadeh, Mohammad Hosein, Noorishadkam, Mahmood, Mirjalili, Seyed Reza, Akbarian-Bafghi, Mohammad Javad, Neamatzadeh, Hossein
Format: Article
Language:English
Subjects:
association
China
Genetic Predisposition to Disease
Humans
interleukin 10
Interleukin-10 - genetics
Kawasaki disease
meta-analysis
Mucocutaneous Lymph Node Syndrome - genetics
polymorphism
Polymorphism, Single Nucleotide
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Summary:This meta-analysis was carried out to evaluate the associations between IL-10 polymorphisms and Kawasaki disease (KD) risk. A comprehensive literature search was performed using PubMed, EMBASE, China National Knowledge Infrastructure and SciELO for all relevant studies evaluating IL-10 polymorphism and susceptibility to KD. The associations were measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs). A total of 13 studies including four studies on -1082 A > G, four studies on -819 T > C and five studies on -592 A > C polymorphism were selected. Pooled data revealed that IL-10 -592 A > C polymorphism was significantly associated with an increased risk of KD (C vs. A: OR = 0.402, 95% CI 0.194-0.832, p = 0.014). However, IL-10 -1082 A > G and -819 T > C polymorphisms were not significantly associated with risk of KD under all five genetic models. Our results revealed that IL-10 -592 A > C polymorphism was associated with risk of KD, while IL-10 -1082 A > G and -819 T > C polymorphisms were not involved in the development of KD.
ISSN:1551-3815
1551-3823
DOI:10.1080/15513815.2019.1686789