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Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity

BACKGROUND AND PURPOSE—The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk of recurrent stroke among patients with minor stroke and transient ischemic attack. We aimed to determine whether the efficacy of clopidogrel-aspirin th...

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Published in:Stroke (1970) 2020-01, Vol.51 (1), p.224-231
Main Authors: Mo, Jinglin, Chen, Zimo, Wang, Anxin, Dai, Liye, Cheng, Aichun, Meng, Xia, Li, Hao, Wang, Yongjun, Johnston, S Claiborne, Wang, Yilong, Zhao, Xingquan, Wang, Zhimin, Li, Bin, Ren, Xudong, Ji, Chunling, Zhang, Guohua, Li, Jianhua, Lu, Bohua, Wang, Liping, Feng, Shutao, Wang, Dali, Li, Juntao, Zhang, Hongtian, Wang, Baojun, Chen, Yuhua, Liu, Bin, Teng, Junfang, Sui, Rubo, Li, Lejun, Lu, Zuneng, Sun, Li, Wang, Dong, Hou, Liying, Yuan, Dongcai, Cao, Yongliang, Li, Hui, Tan, Xiuge, Wang, Huicong, Liu, Mingyi, Liu, Qiuwu, Zhang, Zhong, Cui, Qifu, Wang, Runqing, Zhao, Jialin, Zhang, Jiewen, Bi, Qi, Qi, Xiyou, Li, Changxin, Li, Ling, Pan, Xiaoping, Zhang, Junling, Jiao, Derang, Han, Zhao, Qian, Dawei, Xiao, Jin, Du, Huishan, Huang, Guang, Cui, Yongqiang, Feng, Lianyuan, Xiao, Bo, Cao, Yibin, Wu, Yiping, Liu, Jinfeng, Zhang, Zhiming, Dong, Zhengxie, Wang, Limin, He, Li, Wang, Xinchen, Wang, Ming, Wang, Xiaosha, Zhao, Renliang, Zhou, Shengnian, Hu, Hao, He, Maolin, Yu, Fengchun, Ouyang, Quping, Zhang, Jingbo, Shi, Fuming, Guo, Fuqiang, Wang, Jianfeng, Dou, Ronghua, Wei, Dongning, Meng, Qingwei, Xia, Yilu, Wang, Shimin, Xue, Zhangcang, Ma, Liping, Wang, Chun, Wu, Jiang, Du, Yifeng, Xiao, Lijun, Song, Fucong, Hu, Wenli, Liu, Qingrui, Zhang, Jiemin, Chen, Mei, Yuan, Xiaodong, Liu, Zhihui, Li, Xiaohong, Tian, Tingchen
Format: Article
Language:English
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Summary:BACKGROUND AND PURPOSE—The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk of recurrent stroke among patients with minor stroke and transient ischemic attack. We aimed to determine whether the efficacy of clopidogrel-aspirin therapy among patients with minor stroke / transient ischemic attack was influenced by the stratification of CYP2C19 genotype and body mass index (BMI). METHODS—CYP2C19 loss-of-function allele (LoFA) carriers were defined as patients with either LoFA of *2 or *3. Low/normal weight and overweight/obesity was defined as BMI
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.119.026845