Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma

Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem...

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Published in:Journal of cellular physiology 2020-05, Vol.235 (5), p.4167-4182
Main Authors: Izadpanah, Sama, Shabani, Parastoo, Aghebati‐Maleki, Ali, Baghbanzadeh, Amir, Fotouhi, Ali, Bisadi, Amir, Aghebati‐Maleki, Leili, Baradaran, Behzad
Format: Article
Language:English
Subjects:
Biomarkers, Tumor
Biomedical materials
Bone cancer
Bone Neoplasms - therapy
Bone tumors
Cancer
cancer stem cell
Cell self-renewal
Chemotherapy
Children
Disease resistance
Drug resistance
Gene Expression Regulation, Neoplastic
Humans
Medical treatment
Metastases
Neoplastic Stem Cells - physiology
Osteosarcoma
Osteosarcoma - therapy
Pathogenesis
Phenotypes
Sarcoma
Stem Cell Transplantation - methods
Stem cells
Surgery
treatment
Tumors
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Summary:Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant cells called cancer stem cells (CSCs). OS‐CSCs play a key role in the resistance to treatment and relapse and metastasis through self‐renewal and differentiation abilities. In this review, we intend to go through the different aspects of this malignant disease, including the cancer stem cell‐phenotype, methods for isolating CSCs, signaling pathways, and molecular markers in this disease, and drugs showing resistance in treatment efforts of OS. Osteosarcoma‐cancer stem cells play a key role in the resistance to treatment and relapse and metastasis through self‐renewal and differentiation abilities. In this review, we intend to go through the cancer stem cell‐phenotype, methods for isolating cancer stem cells, signaling pathways and molecular markers in this disease, and drugs showing resistance in treatment efforts of osteosarcoma.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.29344