Morphology, p16, HPV, and outcomes in squamous cell carcinoma of the penis: a multi-institutional study

Our objective was to evaluate the pathologic features and clinical outcomes in cases of invasive penile squamous cell carcinoma (SCC) and the association with p16 immunohistochemistry (IHC) and human papilloma virus (HPV) in situ hybridization (ISH). A retrospective multi-institutional database sear...

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Bibliographic Details
Published in:Human pathology 2020-02, Vol.96, p.79-86
Main Authors: Eich, Marie-Lisa, del Carmen Rodriguez Pena, Maria, Schwartz, Lauren, Granada, Carlos Prieto, Rais-Bahrami, Soroush, Giannico, Giovanna, Amador, Belkiss Murati, Matoso, Andres, Gordetsky, Jennifer B.
Format: Article
Language:English
Subjects:
Age
Aged
Biomarkers, Tumor - analysis
Biopsy
Cancer therapies
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - surgery
Carcinoma, Squamous Cell - virology
Clinical outcomes
Cyclin-Dependent Kinase Inhibitor p16 - analysis
Databases, Factual
Disease Progression
Genital cancers
Histology
Host-Pathogen Interactions
HPV
Human papillomavirus
Human Papillomavirus DNA Tests
Humans
Hybridization
Immunohistochemistry
Male
Metastasis
Middle Aged
Morphology
Mortality
Neoplasm Invasiveness
Neoplasm Recurrence, Local
p16
Papillomaviridae - genetics
Papillomavirus Infections - virology
Pathology
Patients
Penile Neoplasms - chemistry
Penile Neoplasms - pathology
Penile Neoplasms - surgery
Penile Neoplasms - virology
Penis
Retrospective Studies
Risk Assessment
Risk Factors
Squamous cell carcinoma
Treatment Outcome
Tumors
United States
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Summary:Our objective was to evaluate the pathologic features and clinical outcomes in cases of invasive penile squamous cell carcinoma (SCC) and the association with p16 immunohistochemistry (IHC) and human papilloma virus (HPV) in situ hybridization (ISH). A retrospective multi-institutional database search was conducted for invasive SCC of the penis diagnosed between 2007 and 2018 that had undergone surgical resection. Pathologic features, p16 IHC, and HPV ISH were investigated with clinical outcomes. A total of 102 patients were included in the study. The average age was 63 ± 13.3 years. Based on histology, 46% of tumors displayed an HPV-related subtype, whereas p16 was positive in 52% of all cases. Tumor histology correlated well with p16 positivity (P 
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2019.09.013