Clinical characteristics and prognostic factors of malignant tumors involving pterygopalatine fossa

Background To identify the clinical characteristics and prognostic factors of malignancies involving the pterygopalatine fossa (PPF). Methods Fifty‐seven patients who underwent curative surgery for malignant tumor involving PPF were reviewed. Results The rates for three‐year local control (LC), five...

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Bibliographic Details
Published in:Head & neck 2020-02, Vol.42 (2), p.281-288
Main Authors: Woo, Hyun‐Jae, Hwang, Peter H., Kaplan, Michael J., Choby, Garret
Format: Article
Language:English
Subjects:
Head and neck
malignant tumor
maxillary nerve
Medical prognosis
Patients
perineural invasion
prognosis
pterygopalatine fossa
Surgery
Survival
Tumors
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Summary:Background To identify the clinical characteristics and prognostic factors of malignancies involving the pterygopalatine fossa (PPF). Methods Fifty‐seven patients who underwent curative surgery for malignant tumor involving PPF were reviewed. Results The rates for three‐year local control (LC), five‐year disease‐free survival (DFS) and five‐year overall survival (OS) were 55.4%, 34.5%, and 52.7%, respectively. Perineural invasion (PNI) of the maxillary nerve with facial numbness (symptomatic V2 PNI) (P = .04) and cranial involvement (P = .03) were predictors for poor OS. Symptomatic V2 PNI was also a significant predictor for poor LC (P = .05) and DFS (P = .03). Within the subgroup analysis of patients with pathologically confirmed V2 PNI, asymptomatic V2 PNI patients had significantly better LC (71.2% vs 31.8%, P = .05) and DFS (43.8% vs 17.3%, P = .05) compared to symptomatic patients. Conclusion Malignant tumors involving the PPF have diverse pathologies and a poor prognosis. Symptomatic V2 PNI may be an independent poor prognostic factor.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26000