A New Sequence Type of Neisseria meningitidis Serogroup C Associated With a 2016 Meningitis Outbreak in Mali

In 2016, Mali reported a bacterial meningitis outbreak consisting of 39 suspected cases between epidemiologic weeks 9 and 17 with 15% case fatality ratio in the health district of Ouéléssebougou, 80 kilometers from the capital Bamako. Cerebrospinal fluid specimens from 29 cases were tested by cultur...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2019-10, Vol.220 (220 Suppl 4), p.S190-S197
Main Authors: Sanogo, Yibayiri Osee, Guindo, Ibréhima, Diarra, Seydou, Retchless, Adam C, Abdou, Mahamadou, Coulibaly, Souleymane, Maiga, Mahamadou Farka, Coumaré, Mama, Diarra, Bakary, Chen, Alexander, Chang, How-Yi, Vuong, Jeni T, Acosta, Anna M, Sow, Samba, Novak, Ryan T, Wang, Xin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cerebrospinal fluid
Child
Disease Outbreaks
Epidemiology
Female
Genetic Variation
Genome, Bacterial
Genotype
Geography, Medical
History, 21st Century
Humans
Male
Mali - epidemiology
Meningitis
Meningitis, Meningococcal - diagnosis
Meningitis, Meningococcal - epidemiology
Meningitis, Meningococcal - history
Meningitis, Meningococcal - microbiology
Neisseria meningitidis
Neisseria meningitidis, Serogroup C - classification
Neisseria meningitidis, Serogroup C - genetics
Outbreaks
Phylogeny
Polymerase chain reaction
Seasons
Whole Genome Sequencing
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In 2016, Mali reported a bacterial meningitis outbreak consisting of 39 suspected cases between epidemiologic weeks 9 and 17 with 15% case fatality ratio in the health district of Ouéléssebougou, 80 kilometers from the capital Bamako. Cerebrospinal fluid specimens from 29 cases were tested by culture and real-time polymerase chain reaction; 22 (76%) were positive for bacterial meningitis pathogens, 16 (73%) of which were Neisseria meningitidis (Nm). Of the Nm-positive specimens, 14 (88%) were N meningitidis serogroup C (NmC), 1 was NmW, and 1 was nongroupable. Eight NmC isolates recovered by culture from the outbreak were characterized using whole genome sequencing. Genomics analysis revealed that all 8 isolates belonged to a new sequence type (ST) 12446 of clonal complex 10217 that formed a distinct clade genetically similar to ST-10217, a NmC strain that recently caused large epidemics of meningitis in Niger and Nigeria. The emergence of a new ST of NmC associated with an outbreak in the African meningitis belt further highlights the need for continued molecular surveillance in the region.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiz272