Incidence and characteristics of venous thromboembolism in Asian patients with primary central nervous system lymphoma undergoing chemotherapy

Venous thromboembolism (VTE) may lead to diminished quality of life and ultimately worse prognosis in cancer patients, but there is limited data on the incidence, risk factors and mortality impact of VTE in Asian primary central nervous system lymphoma (PCNSL) patients. To report the incidence, risk...

Full description

Saved in:
Bibliographic Details
Published in:Thrombosis research 2019-11, Vol.183, p.131-135
Main Authors: Byun, Ja Min, Hong, Junshik, Yoon, Sung-Soo, Koh, Youngil, Ock, Chan-Young, Kim, Tae Min, Lee, Ji Hyun, Kim, Sung-Hyun, Lee, Jeong-Ok, Bang, Soo-Mee, Yhim, Ho-Young, Bae, Sung Hwa, Mun, Yeung-Chul, Oh, Doyeun
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Asian
Asian Continental Ancestry Group
Central Nervous System Neoplasms - complications
Central Nervous System Neoplasms - drug therapy
Female
Humans
Incidence
Lymphoma - complications
Lymphoma - drug therapy
Male
Middle Aged
Primary central nervous system lymphoma
Retrospective Studies
Risk factor
Venous thromboembolism
Venous Thromboembolism - etiology
Venous Thromboembolism - pathology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Venous thromboembolism (VTE) may lead to diminished quality of life and ultimately worse prognosis in cancer patients, but there is limited data on the incidence, risk factors and mortality impact of VTE in Asian primary central nervous system lymphoma (PCNSL) patients. To report the incidence, risk factors and mortality impact of VTE in Asian PCNSL patients. From 7 academic centers in Korea, 235 newly diagnosed PCNSL patients undergoing chemotherapy were retrospectively identified during period of January 2004 to September 2018. All patients but 12 (6 T-cell, 6 other B-cell) had diffuse large B-cell lymphoma. During the median follow-up of 21 months, 33 patient (14.0%) developed VTE. Of the VTE events, 11 (33.3%) were deep vein thrombosis (DVT), 15 (45.5%) were pulmonary thromboembolism (PTE), and 7 (21.2%) were DVT with PTE. The median time to VTE was 2 months and the one-year actuarial incidence was 11.7%. On multivariate analysis, ECOG performance ≥2, age >60 years, female sex, and Hb
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2019.10.002