Does Gadoterate Meglumine Cause Gadolinium Retention in the Brain of Children? A Case–Control Study

Background Accumulation of macrocyclic gadolinium agents in children's brains remain to be determined. Purpose To demonstrate whether there is an intracranial macrocyclic gadolinium deposition after multiple contrast‐enhanced MRI with gadoterate meglumine in a pediatric population. Study Type R...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetic resonance imaging 2020-05, Vol.51 (5), p.1471-1477
Main Authors: Topcuoglu, Elif Dilara, Topcuoglu, Osman Melih, Semiz Oysu, Aslihan, Bukte, Yasar
Format: Article
Language:English
Subjects:
Adolescent
Age
Brain
Brain - diagnostic imaging
brain MRI
Case-Control Studies
Cerebellar Nuclei - diagnostic imaging
Cerebrospinal fluid
Child
Child, Preschool
Children
contrast
Contrast Media
Correlation
Field strength
Gadolinium
gadolinium accumulation
Gadolinium DTPA
Humans
macrocyclic
Magnetic Resonance Imaging
Medical imaging
Meglumine - adverse effects
Neuroimaging
Organometallic Compounds - adverse effects
Pons
Population studies
Retention
Retrospective Studies
Skull
Statistical analysis
Statistical tests
Substantia alba
Thalamus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Accumulation of macrocyclic gadolinium agents in children's brains remain to be determined. Purpose To demonstrate whether there is an intracranial macrocyclic gadolinium deposition after multiple contrast‐enhanced MRI with gadoterate meglumine in a pediatric population. Study Type Retrospective case–control. Population In all, 45 children (age range: 5–17 years; mean, 13.7 ± 3.4 years) for the study group and 45 healthy children (age range: 5–17 years; mean, 13.7 ± 3.4 years) for the control group. Field Strength/Sequence T1‐ and T2‐weighted axial images on a 1.5T scanner. Assessment Children with at least three enhanced brain MRIs and an age‐ and sex‐matched control group with an unenhanced brain MRIs were compared in terms of T1 signal intensity (SI). All patients in the study group received gadoterate meglumine intravenously (0.1 mmol/kg). SI measurements were made by drawing six regions of interest (ROIs): dentate nuclei (DN), pons, globus pallidi (GP), frontal white matter (FWM), thalamus (T), clivus, and cerebrospinal fluid (CSF) for both groups on unenhanced T1‐weighted images. Statistical Tests Student's t‐test was used for comparison of SI. The Pearson correlation was calculated for the correlation between the SI and the number of gadolinium administrations. Results A significant difference was detected between two groups for DN/CSF, pons/CSF, GP/CSF, thalamus/CSF, and FWM/CSF (P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.26954