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Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emergin...
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| Published in: | Journal of cellular physiology 2020-05, Vol.235 (5), p.4146-4152 |
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| container_end_page | 4152 |
| container_issue | 5 |
| container_start_page | 4146 |
| container_title | Journal of cellular physiology |
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| creator | Rahmani, Farzad Ziaeemehr, Aghigh Shahidsales, Soodabeh Gharib, Masoumeh Khazaei, Majid Ferns, Gordon A. Ryzhikov, Mikhail Avan, Amir Hassanian, Seyed M. |
| description | Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC.
Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling axis. The present study summarizes the major findings about the regulatory role of miRNAs in PI3K/AKT/mTOR pathway in the pathogenesis of hepatocellular carcinoma. |
| doi_str_mv | 10.1002/jcp.29333 |
| format | article |
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Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling axis. The present study summarizes the major findings about the regulatory role of miRNAs in PI3K/AKT/mTOR pathway in the pathogenesis of hepatocellular carcinoma.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.29333</identifier><identifier>PMID: 31663122</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Animals ; Apoptosis ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Hepatocellular carcinoma ; Humans ; Kinases ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Metabolism ; microRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Morbidity ; Pathogenesis ; Phosphatidylinositol 3-Kinases - genetics ; Phosphatidylinositol 3-Kinases - metabolism ; PI3K/AKT/mTOR pathway ; Proto-Oncogene Proteins c-akt - genetics ; Proto-Oncogene Proteins c-akt - metabolism ; Rapamycin ; Signaling ; TOR protein ; TOR Serine-Threonine Kinases - genetics ; TOR Serine-Threonine Kinases - metabolism ; Tumors</subject><ispartof>Journal of cellular physiology, 2020-05, Vol.235 (5), p.4146-4152</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4593-c58beb864dfab5b392070cc2747270afbbcb108bbcbd575ac7e8a823462970693</citedby><cites>FETCH-LOGICAL-c4593-c58beb864dfab5b392070cc2747270afbbcb108bbcbd575ac7e8a823462970693</cites><orcidid>0000-0002-5247-4043 ; 0000-0002-4968-0962 ; 0000-0002-7979-5699</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.29333$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.29333$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31663122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahmani, Farzad</creatorcontrib><creatorcontrib>Ziaeemehr, Aghigh</creatorcontrib><creatorcontrib>Shahidsales, Soodabeh</creatorcontrib><creatorcontrib>Gharib, Masoumeh</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Ryzhikov, Mikhail</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><creatorcontrib>Hassanian, Seyed M.</creatorcontrib><title>Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC.
Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling axis. The present study summarizes the major findings about the regulatory role of miRNAs in PI3K/AKT/mTOR pathway in the pathogenesis of hepatocellular carcinoma.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Metabolism</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Morbidity</subject><subject>Pathogenesis</subject><subject>Phosphatidylinositol 3-Kinases - genetics</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>PI3K/AKT/mTOR pathway</subject><subject>Proto-Oncogene Proteins c-akt - genetics</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Rapamycin</subject><subject>Signaling</subject><subject>TOR protein</subject><subject>TOR Serine-Threonine Kinases - genetics</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><subject>Tumors</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PwkAQhjdGI4ge_AOmiRc9lO5Hd7c9EuIHQoQQPDfbZQtL2i7u0hj-vVtADyaeJpl55s3MA8Atgn0EIY42ctvHKSHkDHQRTHkYM4rPQdfPUJjSGHXAlXMbCGHqqUvQIYgxgjDugvXclCowRWDVqinFzth9UOn5-8C1zd1aBbMRGUeD8SKqFtN54PSqFqWuV4GuD-Ot2K3NStXK6cPKWvmOkaosfZwNpLBS16YS1-CiEKVTN6faAx_PT4vhaziZvoyGg0koY5qSUNIkV3nC4mUhcpqTFEMOpcQ85phDUeS5zBFM2rKknArJVSISTGKGUw5ZSnrg4Zi7teazUW6XVdq154hamcZlmCDIaMJZ4tH7P-jGNNa_11KUxN5cwjz1eKSkNc5ZVWRbqyth9xmCWas_8_qzg37P3p0Sm7xSy1_yx7cHoiPwpUu1_z8pexvOjpHfFMeNew</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Rahmani, Farzad</creator><creator>Ziaeemehr, Aghigh</creator><creator>Shahidsales, Soodabeh</creator><creator>Gharib, Masoumeh</creator><creator>Khazaei, Majid</creator><creator>Ferns, Gordon A.</creator><creator>Ryzhikov, Mikhail</creator><creator>Avan, Amir</creator><creator>Hassanian, Seyed M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5247-4043</orcidid><orcidid>https://orcid.org/0000-0002-4968-0962</orcidid><orcidid>https://orcid.org/0000-0002-7979-5699</orcidid></search><sort><creationdate>202005</creationdate><title>Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma</title><author>Rahmani, Farzad ; Ziaeemehr, Aghigh ; Shahidsales, Soodabeh ; Gharib, Masoumeh ; Khazaei, Majid ; Ferns, Gordon A. ; Ryzhikov, Mikhail ; Avan, Amir ; Hassanian, Seyed M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4593-c58beb864dfab5b392070cc2747270afbbcb108bbcbd575ac7e8a823462970693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Metabolism</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>Morbidity</topic><topic>Pathogenesis</topic><topic>Phosphatidylinositol 3-Kinases - genetics</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>PI3K/AKT/mTOR pathway</topic><topic>Proto-Oncogene Proteins c-akt - genetics</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Rapamycin</topic><topic>Signaling</topic><topic>TOR protein</topic><topic>TOR Serine-Threonine Kinases - genetics</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahmani, Farzad</creatorcontrib><creatorcontrib>Ziaeemehr, Aghigh</creatorcontrib><creatorcontrib>Shahidsales, Soodabeh</creatorcontrib><creatorcontrib>Gharib, Masoumeh</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Ryzhikov, Mikhail</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><creatorcontrib>Hassanian, Seyed M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahmani, Farzad</au><au>Ziaeemehr, Aghigh</au><au>Shahidsales, Soodabeh</au><au>Gharib, Masoumeh</au><au>Khazaei, Majid</au><au>Ferns, Gordon A.</au><au>Ryzhikov, Mikhail</au><au>Avan, Amir</au><au>Hassanian, Seyed M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2020-05</date><risdate>2020</risdate><volume>235</volume><issue>5</issue><spage>4146</spage><epage>4152</epage><pages>4146-4152</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><notes>Farzad Rahmani and Aghigh Ziaeemehr made an equal contribution to this study.</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC.
Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling axis. The present study summarizes the major findings about the regulatory role of miRNAs in PI3K/AKT/mTOR pathway in the pathogenesis of hepatocellular carcinoma.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31663122</pmid><doi>10.1002/jcp.29333</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5247-4043</orcidid><orcidid>https://orcid.org/0000-0002-4968-0962</orcidid><orcidid>https://orcid.org/0000-0002-7979-5699</orcidid></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Hepatocellular carcinoma Humans Kinases Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Metabolism microRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA Morbidity Pathogenesis Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism PI3K/AKT/mTOR pathway Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rapamycin Signaling TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Tumors |
| title | Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma |
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