Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emergin...

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Bibliographic Details
Published in:Journal of cellular physiology 2020-05, Vol.235 (5), p.4146-4152
Main Authors: Rahmani, Farzad, Ziaeemehr, Aghigh, Shahidsales, Soodabeh, Gharib, Masoumeh, Khazaei, Majid, Ferns, Gordon A., Ryzhikov, Mikhail, Avan, Amir, Hassanian, Seyed M.
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Animals
Apoptosis
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Hepatocellular carcinoma
Humans
Kinases
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Metabolism
microRNA
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Morbidity
Pathogenesis
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
PI3K/AKT/mTOR pathway
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
Rapamycin
Signaling
TOR protein
TOR Serine-Threonine Kinases - genetics
TOR Serine-Threonine Kinases - metabolism
Tumors
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Summary:Hepatocellular carcinoma (HCC) is one of the common malignant human tumors with high morbidity worldwide. Aberrant activation of the oncogenic phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling is related to clinicopathological features of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the PI3K/AKT/mTOR signaling axis. The recognition of the crucial role of miRNAs in hepatocarcinogenesis represents a promising area to identify novel anticancer therapeutics for HCC. The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC. Emerging data revealed that microRNAs (miRNAs) have prominent implications for regulating cellular proliferation, differentiation, apoptosis, and metabolism through targeting the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling axis. The present study summarizes the major findings about the regulatory role of miRNAs in PI3K/AKT/mTOR pathway in the pathogenesis of hepatocellular carcinoma.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.29333