Hypofractionated radiotherapy for non-metastatic bone and soft tissue sarcomas

To evaluate the efficacy and toxicity of hypofractionated radiotherapy in non-metastatic soft tissue and bone sarcomas. Thirty patients underwent hypofractionated radiotherapy between 2007 and 2015. Overall, 17 patients underwent primary hypofractionated radiotherapy, nine underwent hypofractionated...

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Bibliographic Details
Published in:Cancer radiothérapie 2019-12, Vol.23 (8), p.853-859
Main Authors: Yuce Sari, S., Cengiz, M., Dauletkazin, A., Yazici, G., Gultekin, M., Hurmuz, P., Yildiz, F., Zorlu, F., Gurkaynak, M., Akyol, F., Ozyigit, G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bone Neoplasms - mortality
Bone Neoplasms - pathology
Bone Neoplasms - radiotherapy
Child
Disease-Free Survival
Female
Humans
Hypofractionation
Hypofractionnement
Male
Middle Aged
Neoplasm Recurrence, Local - mortality
Radiation Dose Hypofractionation
Radiotherapy
Radiotherapy, Adjuvant - methods
Radiothérapie
Radiothérapie en conditions stéréotaxiques
Re-Irradiation - methods
Sarcoma
Sarcoma - mortality
Sarcoma - pathology
Sarcoma - radiotherapy
Sarcome
Soft Tissue Neoplasms - mortality
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - radiotherapy
Stereotactic body radiotherapy
Survival Rate
Tumor Burden
Young Adult
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Summary:To evaluate the efficacy and toxicity of hypofractionated radiotherapy in non-metastatic soft tissue and bone sarcomas. Thirty patients underwent hypofractionated radiotherapy between 2007 and 2015. Overall, 17 patients underwent primary hypofractionated radiotherapy, nine underwent hypofractionated radiotherapy for reirradiation, and four received a boost dose via hypofractionated radiotherapy after external beam radiotherapy. Most common disease sites were head and neck and retroperitoneum. Hypofractionated radiotherapy was administered with a definitive, adjuvant, or neoadjuvant intent. Median age was 37 years (range: 11–82 years). Median hypofractionated radiotherapy dose was 35Gy (range: 20–50Gy) in three to five fractions. Median follow-up was 21 months (range: 1–108 months). One- and 2-year overall survival rate was 75% and 52%, respectively. One- and 2-year local recurrence-free survival rate was 59% and 48%, with local recurrence rates of 16% and 33% in 1 and 2 years, respectively. Univariate analysis revealed tumour size (P=0.04), hypofractionated radiotherapy intent (P=0.016) and reirradiation (P=0.001) as prognostic factors for local recurrence-free survival. Severe late toxicity was observed in one patient as grade 3 trismus. Hypofractionated radiotherapy as the primary treatment or for reirradiation has been shown to be safe in the treatment of bone and soft tissue sarcomas. It can provide relatively good local control and survival rates. Il s’agissait d’évaluer l’efficacité et la toxicité de la radiothérapie hypofractionnée des sarcomes non métastatiques des tissus mous et des os. Trente patients ont bénéficié d’une radiothérapie hypofractionnée entre 2007 et 2015. Dans l’ensemble, 17 patients ont reçu une radiothérapie primaire hypofractionnée, neuf une réirradiation hypofractionnée et quatre ont reçu une dose de boost de radiothérapie hypofractionnée suite à la radiothérapie externe. Les sites tumoraux les plus courants étaient la tête, le cou et le rétropéritoine. La radiothérapie hypofractionnée a été administrée avec une intention définitive, adjuvante ou néoadjuvante. L’âge médian était de 37 ans (extrêmes : 11–82 ans). La dose médiane de radiothérapie hypofractionnée était de 35Gy (extrêmes : 20–50Gy) en trois à cinq fractions. La durée de suivi médiane était de 21 mois (extrêmes : 1–108 mois). Les taux de survie globale à un, deux et cinq ans étaient respectivement de 75 %, 52 % et 28 %. Les taux de survie sans récidive locale à un,
ISSN:1278-3218
1769-6658
DOI:10.1016/j.canrad.2019.06.011