Changes in Microbiota and Development of Nonspecific Inflammation of Genitals in Female C57Bl/6 Mice after Aerosol Infection with Mycobacterium tuberculosis

Infectious process even at the initial stage after aerosol infection with Mycobacterium tuberculosis induced rapid changes in vaginal microbiota in mice. Rapid decrease in both the quantity and diversity of microbiota was noted, and then, partial recovery of normal flora was observed. Changes in vag...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-09, Vol.167 (5), p.645-649
Main Authors: Kayukova, S. I., Donnikov, A. E., Bocharova, I. V., Tumanova, E. L., Gergert, V. Ya, Ergeshov, A. E., Nikonenko, B. V.
Format: Article
Language:English
Subjects:
Animal experimentation
Animals
Bacterial Load
Biomedical and Life Sciences
Biomedicine
Cell Biology
Clostridium - isolation & purification
Dysbiosis - microbiology
Dysbiosis - pathology
Eubacterium - isolation & purification
Female
Health aspects
Immunology and Microbiology
Inflammation
Internal Medicine
Laboratory Medicine
Lung - microbiology
Lung - pathology
Mice
Mice, Inbred C57BL
Microbiota
Microbiota (Symbiotic organisms)
Mycobacterium tuberculosis - pathogenicity
Mycobacterium tuberculosis - physiology
Pathology
Peptostreptococcus - isolation & purification
Porphyromonas - isolation & purification
Prevotella - isolation & purification
Reproductive organs
Streptococcus - isolation & purification
Tuberculosis
Tuberculosis, Pulmonary - microbiology
Tuberculosis, Pulmonary - pathology
Vagina - microbiology
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Summary:Infectious process even at the initial stage after aerosol infection with Mycobacterium tuberculosis induced rapid changes in vaginal microbiota in mice. Rapid decrease in both the quantity and diversity of microbiota was noted, and then, partial recovery of normal flora was observed. Changes in vaginal microbiota was detected as soon as in 3-7 days after lung infection, while inflammatory changes appeared by day 35. At the early stage of infection, no signs of inflammation were observed, neither M. tuberculosis nor its DNA were detected in mouse genital organs.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-019-04589-8