Effects of lysosomal deposition on the friction coefficient of hydrogel contact lenses

•Lysozyme results in an increase of friction coefficient on Ocufilcon-D and Hefilcon-A lens.•Lysozyme has no effect on friction coefficient of Nelfilcon-A lens.•The amount of lysosomal deposition is high on all the contact lens when the environmental lysozyme is high.•The developed contact lens care...

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Bibliographic Details
Published in:Contact lens & anterior eye 2020-04, Vol.43 (2), p.144-148
Main Authors: Su, Chen-Ying, Yeh, Lung-Kun, Lai, Chi-Chun, Li, Kuan-Yi, Tseng, Ching-Li, Fang, Hsu-Wei
Format: Article
Language:English
Subjects:
Friction coefficient
Hydrogel contact lens
Lysozyme deposition
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Summary:•Lysozyme results in an increase of friction coefficient on Ocufilcon-D and Hefilcon-A lens.•Lysozyme has no effect on friction coefficient of Nelfilcon-A lens.•The amount of lysosomal deposition is high on all the contact lens when the environmental lysozyme is high.•The developed contact lens care solution can effectively remove deposited lysozyme from all the contact lens.•The developed contact lens care solution can reduce friction coefficient that is caused by lysozyme. When a contact lens is in contact with the eyelid and the cornea, tear proteins start to be accumulated on the lens and may subsequently undergo conformational changes. Protein adsorption or conformational changes on the lens may lead to discomfort, red eye, or even inflammatory reactions. Although measuring the friction coefficient of contact lens has been linked to comfort degree in vivo, there is not much research about the effects of tear protein deposition on the friction coefficient of the contact lens. Therefore, we investigated the friction coefficient of three distinct materials of contact lenses in two different lysosomal concentrations. We also studied lysozyme deposition on the lens without the influence of friction. The results demonstrated that although the amount of lysozyme deposition was high on all the materials we tested, it was not corresponded to higher friction coefficient. In addition, we investigated the effect of the contact lens care solution we developed on friction coefficient and lysozyme deposition of three different materials of contact lenses. The results showed that the care solution could reduce the increased friction coefficient caused by high lysosomal concentration. Therefore, we proposed a potential mechanism of why lysosomal deposition may result in high friction coefficient for certain types of hydrogel contact lenses.
ISSN:1367-0484
1476-5411
DOI:10.1016/j.clae.2019.09.007