Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents

This study investigated the effect of terpinen-4-ol against complex and its interactions with antifungals. The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm acti...

Full description

Saved in:
Bibliographic Details
Published in:Future microbiology 2019-09, Vol.14 (14), p.1221-1233
Main Authors: Brilhante, Raimunda Sn, Pereira, Vandbergue S, Oliveira, Jonathas S, Rodrigues, Anderson M, de Camargo, Zoilo P, Pereira-Neto, Waldemiro A, Nascimento, Nilberto Rf, Castelo-Branco, Débora Scm, Cordeiro, Rossana A, Sidrim, José Jc, Rocha, Marcos Fg
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal agents
Antifungal Agents - pharmacology
Biofilms
Biofilms - drug effects
Drug Synergism
Drugs
Ergosterol
Ergosterol - analysis
Experiments
Fungi
Itraconazole
Laboratories
Microbial Sensitivity Tests
Microorganisms
Natural products
Oils & fats
Potassium
Spectrophotometry
Sporothrix
Sporothrix - drug effects
Sporothrix - growth & development
Sporothrix schenckii
Sterols
Synergism
Terbinafine
Terpenes - pharmacology
Terpinene
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study investigated the effect of terpinen-4-ol against complex and its interactions with antifungals. The antifungal activity of terpinen-4-ol was evaluated by broth microdilution. The potential effect on cellular ergosterol concentration was evaluated by spectrophotometry. The antibiofilm activity was evaluated by violet crystal staining and XTT reduction assay. The potential pharmacological interactions with antifungals were evaluated by the checkerboard assay. terpinen-4-ol (T-OH) showed minimal inhibitory concentrations ranging from 4 to 32 mg/l decreasing cellular ergosterol content and presented a SMIC ranging from 64 to 1024 mg/l for spp. The combinations of T-OH with itraconazole or terbinafine were synergistic. T-OH has antifungal activity against spp. and acts synergistically with standard antifungals.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2019-0146