Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people

Prospective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. Furthermore, the extent to which established risk factors account for such associations requires further elucidation. We used UK Biobank baseline cognitive d...

Full description

Saved in:
Bibliographic Details
Published in:Alzheimer's & dementia 2019-12, Vol.15 (12), p.1546-1557
Main Authors: Calvin, Catherine M., Wilkinson, Tim, Starr, John M., Sudlow, Cathie, Hagenaars, Saskia P., Harris, Sarah E., Schnier, Christian, Davies, Gail, Fawns-Ritchie, Chloe, Gale, Catharine R., Gallacher, John, Deary, Ian J.
Format: Article
Language:eng
Subjects:
ROC
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prospective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. Furthermore, the extent to which established risk factors account for such associations requires further elucidation. We used UK Biobank baseline cognitive data (n ≤ 488,130) and electronically linked hospital inpatient and death records during three- to eight-year follow-up, to estimate risk of total dementia (n = 1051), Alzheimer's disease (n = 352), and vascular dementia (n = 169) according to four brief cognitive tasks, with/without adjustment for constitutional and modifiable risk factors. We found associations of cognitive task performance with all-cause and cause-specific dementia (P 
ISSN:1552-5260
1552-5279