Osteocalcin Regulates Arterial Calcification Via Altered Wnt Signaling and Glucose Metabolism

ABSTRACT Arterial calcification is an important hallmark of cardiovascular disease and shares many similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an established marker of vascular smooth muscle cell (VSMC) osteochondrogenic transdifferentiation and a known...

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Bibliographic Details
Published in:Journal of bone and mineral research 2020-02, Vol.35 (2), p.357-367
Main Authors: Rashdan, Nabil A, Sim, Alisia M, Cui, Lin, Phadwal, Kanchan, Roberts, Fiona L, Carter, Roderick, Ozdemir, Derya D, Hohenstein, Peter, Hung, John, Kaczynski, Jakub, Newby, David E, Baker, Andrew H, Karsenty, Gerard, Morton, Nicholas M, MacRae, Vicky E
Format: Article
Language:English
Subjects:
Animals
ARTERIAL CALCIFICATION
Arteriosclerosis
Calcification
Calcification (ectopic)
Calcium
Cardiovascular diseases
Carotid artery
Cbfa-1 protein
Cells, Cultured
Cyclin D
Electron transport
Gene expression
Glucose
Glucose metabolism
Immunohistochemistry
Localization
Metabolism
Mice
Mineralization
Mitochondria
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle
OSTEOCALCIN
Osteocalcin - genetics
Phosphate transporter
Pit1 protein
Plaques
Respiration
Smooth muscle
Therapeutic applications
Vascular Calcification
Wnt protein
WNT SIGNALING
Wnt Signaling Pathway
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Summary:ABSTRACT Arterial calcification is an important hallmark of cardiovascular disease and shares many similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an established marker of vascular smooth muscle cell (VSMC) osteochondrogenic transdifferentiation and a known regulator of glucose metabolism. However, the role of OCN in controlling arterial calcification is unclear. We hypothesized that OCN regulates calcification in VSMCs and sought to identify the underpinning signaling pathways. Immunohistochemistry revealed OCN co‐localization with VSMC calcification in human calcified carotid artery plaques. Additionally, 3 mM phosphate treatment stimulated OCN mRNA expression in cultured VSMCs (1.72‐fold, p
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.3888