Magnetically Actuated SiCN‐Based Ceramic Microrobot for Guided Cell Delivery

A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by...

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Bibliographic Details
Published in:Advanced healthcare materials 2019-11, Vol.8 (21), p.e1900739-n/a
Main Authors: Gyak, Ki‐Won, Jeon, Sungwoong, Ha, Laura, Kim, Sangwon, Kim, Jin‐young, Lee, Kwang‐Sup, Choi, Hongsoo, Kim, Dong‐Pyo
Format: Article
Language:English
Subjects:
Biocompatibility
biocompatible materials
cell delivery
ceramic microrobots
Ceramics
Inert atmospheres
Magnetic fields
magnetic nanoparticles
Mammalian cells
Microrobots
Nanoparticles
Organic chemistry
Pyrolysis
Silicon carbonitride
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Summary:A silicon carbonitride (SICN) ceramic microrobot, biocompatible and magnetically activable, is developed for the delivery of viable cells to defective tissue by sequential steps of microstructuring, magnetization, and cell loading. The ceramic carrier of porous cylindrical framework is fabricated by 3D laser lithography using a photocurable preceramic polymer, chemically modified polyvinylsilazane, and subsequent pyrolysis at 600 °C under an inert atmosphere. Magnetic nanoparticles (MNP) are integrated into the surface‐modified ceramic carrier by thiol‐ene click reaction. Finally, the microrobot is loaded with fibroblast cells, which can be guided by a rotating external magnetic field. The proposed ceramic microrobot is mechanically durable, adequately controllable with external magnetic field, and quite compatible with mammalian cells. Biocompatible magnetically actuated silicon carbonitride ceramic microrobots are developed for biomedical applications. The microrobots are fabricated by 3D laser lithography using a photocurable preceramic polymer and converted to ceramics by subsequent pyrolysis. Magnetic nanoparticles are integrated onto the surface for magnetic actuation. The microrobots loaded with fibroblast cells are actuated with directionality by an external magnetic field.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201900739